Healthy Age-matched Older Adults Clinical Trial
— VROfficial title:
Application of VR-based Working Memory Screening Test to Facilitate Early Detection of Dementia
We propose to validate an interactive, immersive spatial memory test from the laboratory test. This VR-based working memory test (VRWMT) is a first-person, self-pacing game embedded within a virtual reality environment, the program is easily implemented with minimal instructions and no supervision that can be community-users friendly. It is specifically designed to assess rapid spatial working memory - a common deficit in all NCD subtypes. Its ability to detect pathological models of dementia, age-related deterioration, and hippocampal dysfunction are well established in literature
| Status | Not yet recruiting |
| Enrollment | 160 |
| Est. completion date | December 31, 2022 |
| Est. primary completion date | December 30, 2022 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | 65 Years to 80 Years |
| Eligibility | Inclusion Criteria: - the ability to understand verbal and written Chinese instructions - the ability and willingness to provide informed consent and sign the relevant document. Exclusion Criteria: - a history of substance abuse including alcohol, drugs, or any medication/substances indicative of chronic abuse; - participants with major NCD. |
| Country | Name | City | State |
|---|---|---|---|
| n/a | |||
| Lead Sponsor | Collaborator |
|---|---|
| The Hong Kong Polytechnic University | Department of Neuroscience, Psychology and Behavior. The University of Leicester, School of Psychology, The University of Nottingham, The Alice Ho Miu Ning Nethersole Hospital |
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Daugherty AM, Raz N. A virtual water maze revisited: Two-year changes in navigation performance and their neural correlates in healthy adults. Neuroimage. 2017 Feb 1;146:492-506. doi: 10.1016/j.neuroimage.2016.09.044. Epub 2016 Sep 19. — View Citation
Daugherty AM, Yuan P, Dahle CL, Bender AR, Yang Y, Raz N. Path Complexity in Virtual Water Maze Navigation: Differential Associations with Age, Sex, and Regional Brain Volume. Cereb Cortex. 2015 Sep;25(9):3122-31. doi: 10.1093/cercor/bhu107. Epub 2014 May — View Citation
Folley BS, Astur R, Jagannathan K, Calhoun VD, Pearlson GD. Anomalous neural circuit function in schizophrenia during a virtual Morris water task. Neuroimage. 2010 Feb 15;49(4):3373-84. doi: 10.1016/j.neuroimage.2009.11.034. Epub 2009 Dec 4. — View Citation
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Delayed matching-to-place (DMP) | a prototypical working memory test implemented in a virtual reality environment of the VRWMT | 20 mins | |
| Primary | The Montreal Cognitive Assessment - Hong Kong Version | The MoCA-HK is an examiner-rated cognitive screening test that evaluates visuospatial functions, naming, attention and working memory, language, abstraction, and orientation, commonly affected in NCD including Alzheimer's disease, stroke, and vascular dementia. It is a validated tool for detecting cognitive impairment in Chinese Hong Kong population at early stages. It is a common tool in practical practice that can be under 15 minutes. MoCA scores range from 0 to 30. Subjects with a score of above 21 will be classified as "healthy controls", while 21 or below will be included in the mild NCD group in the present study. | 15 mins | |
| Primary | The Chinese Multiple Errands Test | A functional performance measure of executive function that identifies abnormalities known for its ecological validity through assessment of real-world daily living activities. The proposed study will evaluate the ability of working memory (as a component to executive function) from VRWMT to predict executive functions (globally) across the six scores obtained from the Chinese Multiple Errands Test | 20 mins | |
| Primary | Biological biomarkers for older adults with NCDs and Healthy Control | The panel of biomarkers covers five immune cytokines and two metabolic markers (including serum IL-1B,Interleukin 6, Interleukin 10, Interleukin 33, Tumor Necrosis Factor alpha, Leptin and Glycosylated haemoglobin A1c (HbA1c) | 5 mins |