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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT06333756
Other study ID # YM110099E
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date May 1, 2021
Est. completion date August 1, 2022

Study information

Verified date December 2022
Source National Yang Ming University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

We will explored the effect of cross education training on different cortex functional connectivity, cortex and muscle functional connectivity, and maximal voluntary contraction. Healthy participants receive cross education training of the elbow flexor (12 rep./set, 3sets, 60%MVC, 180°/s, eccentric).Maximal voluntary contraction, electroencephalogram and electromyogram will record during cross education tasks to determine the effects of cross education training on cortical network and muscle functional connectivity


Description:

Cross education (CE) training was observed in 1894, when unilateral strength training of single limb was found to increase in strength of untrained muscle group. CE has potential clinical relevance in rehabilitation for patient who have acute injuries of the limb, post-surgical limb immobilization and certain neurological disorders with unilateral muscle weakness. Although CE has several potential clinical application, the precise physiological mechanisms underlying CE remains unknown. Previous studies reported that CE may involve bilateral cortical activity in both contralateral primary motor cortex (cM1), and ipsilateral primary motor cortex (iM1).In addition, neuroimaging studies have demonstrated that bilateral supplementary motor area, but CE immediate change of functional connectivity in cortical network remains unknown. The purposes of this study are to investigate the immediate effect of CE training of biceps brachii (1) Immediate change of functional connectivity in cortical network; (2) Immediate change of functional connectivity in cortex and target muscle; (3) Explore immediate change of corticomuscular functional connectivity on maximal voluntary contraction. We hypothesize that (1) Bilateral cortical motor network that exhibit changes in functional connectivity during cross education; (2) Cross education would immediately enhance functional connectivity between cortex and target muscle; (3) Cross education would immediately change corticomuscular functional connectivity on maximal isometric voluntary contraction.


Recruitment information / eligibility

Status Completed
Enrollment 40
Est. completion date August 1, 2022
Est. primary completion date April 30, 2022
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 20 Years to 40 Years
Eligibility Inclusion Criteria: 1. Healthy adults who are 20-40 years old Exclusion Criteria: 1. Upper extremity (UE) pain or discomfort 2. Medical condition that substantially influenced their UE strength 3. Experience of UE surgery 4. Paresthesia in UE 5. Open wound on UE

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Cross education
Cross education training of the biceps brachii (12 rep./set, 3sets, 60%MVIC,180°/s, eccentric contraction)

Locations

Country Name City State
Taiwan National Yang-Ming University Taipei

Sponsors (1)

Lead Sponsor Collaborator
National Yang Ming University

Country where clinical trial is conducted

Taiwan, 

Outcome

Type Measure Description Time frame Safety issue
Primary Corticocortical coherence Level of electroencephalography and electromyography synchronization in frequency domain when participants maintain 20% maximal voluntary contraction Measured immediately after cross education training
Primary Corticomuscular coherence Level of electroencephalography and electromyography synchronization in frequency domain when participants maintain 20% maximal voluntary contraction Measured immediately after cross education training
Primary Maximal voluntary contraction The ability to generate maximal voluntary elbow flexor force Measured immediately after cross education training
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