Effect of Probiotic on the Gut Microbiota of Healthy Volunteers

Status Completed

Clinical Trial Summary

The goal of this placebo-controlled randomized trial is to test the effect of intervention with Bifidobacterium animalis subsp. lactis BLa80 on the composition of the gut microbiota of healthy volunteers. The main question it aims to answer is whether probiotic can effectively regulate intestinal flora. Participants will take a package of probiotics every day, and their weight was recorded once a week using a weight scale. Blood and stool tests were conducted before and after taking probiotics.

Clinical Trial Description

This placebo-controlled study aims to investigate the effect of Bifidobacterium animalis subsp. lactis BLa80 supplementation on the status of the gut microbiota of healthy participants. 112 subjects were randomly divided into a placebo group (maltodextrin) and a Bla80 group (maltodextrin + strain BLa80 in 1 × 10 10 colony-forming units/day). The intervention lasted 8 weeks, and 16S rRNA sequencing technology was used to study the changes in gut microbiota between different groups. Simultaneously, clinical indicators such as alanine transaminase (ALT), aspartate aminotransferase (AST), and uric acid (UC) were measured to illustrate the metabolic effects of BLa80. ;

Study Design

Related Conditions & MeSH terms

Healthy Adults

Clinical Trial Details

NCT number	NCT06103253
Study type	Interventional
Source	Wecare Probiotics Co., Ltd.
Contact
Status	Completed
Phase	N/A
Start date	April 20, 2023
Completion date	June 28, 2023

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT04677920` - The Healthy Cookie Energy Study: Understanding How Healthy Cookies Affect Mitochondrial Biology	N/A
Active, not recruiting	`NCT03312920` - Investigating Memory Retrieval Improvement in Healthy Subjects	N/A
Completed	`NCT03309072` - Investigating Accelerated Learning and Memory in Healthy Subjects Using a Face Name Memory Task	N/A
Completed	`NCT03289832` - Effect of Orally Delivered Phytochemicals on Aging and Inflammation in the Skin	N/A
Enrolling by invitation	`NCT06133530` - Human Milk Oligosaccharides (HMOs) and Gut Microbiota, Immune System in Antarctica	N/A
Completed	`NCT05141903` - Dietary Supplement With and Without a Probiotic and/or Antibiotic
Completed	`NCT01689259` - Comparative Pharmacokinetics and Safety of TNX-102 SL Tablets and Cyclobenzaprine Oral Tablet in Healthy Adults	Phase 1
Completed	`NCT01187875` - Resistant Starch and Satiety	Phase 0
Completed	`NCT03312699` - Effects of Aging on Primary and Secondary Vaccine Responses in a 15-Year Longitudinal Cohort	Phase 1
Completed	`NCT03319134` - Investigating the Neural Correlates in Memory Retrieval After HD-tDCS	N/A
Recruiting	`NCT04104360` - Galacto-oligosaccharides and Intestinal Activity	N/A
Completed	`NCT03228693` - Gene Expression and Biomarker Profiling of Keloid Skin	N/A
Completed	`NCT04146532` - Aspirin Effects on Emotional Reactions	Early Phase 1
Completed	`NCT04206293` - A Study to Evaluate The Impact on Skin Quality Attributes by Juvederm® Volite Injection on Healthy Volunteers	N/A
Recruiting	`NCT06011018` - Comparison of Effects of Mirror Therapy Combined With Neuromuscular Electrical Stimulation or Binaural Beats Stimulation on Cortical Excitability, Heart Rate Variability and Lower Limb Motor Function in Patients With Stroke	N/A
Completed	`NCT05093205` - STUDY TO EVALUATE THE EFFECT OF PF-06882961 ON SINGLE DOSE ATORVASTATIN, MEDAZOLAM AND ORALCONTRACEPTIVE PHARMACOKINETICS IN HEALTHY ADULT PARTICIPANTS	Phase 1
Completed	`NCT04596709` - Investigation of Blood Glucose and Insulin Response After Intake of Vitalose	N/A
Completed	`NCT04272450` - Respiratory Muscle Strength in Different Age Groups
Completed	`NCT02044679` - Evaluation of Spot Urine as a Biomarker of Fluid Intake in Real Life Conditions	N/A
Completed	`NCT01402973` - Pilot Study of a Dietary Intervention Based Upon Advanced Glycation End Products	N/A