Activity Breaks for Brain Health in Adolescents

Healthy Adolescents Clinical Trial

— ABBaH teens  

Official title:

Acute Effects From Prolonged Inactivity and Physical Activity Interventions on Cortical Blood Flow and Arterials Stiffness in School-aged Adolescents.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04552626
• Other study ID #: Dnr 2020-02597
• Status: Completed
• Phase: N/A
• Start date: September 17, 2020
• Est. completion date: December 16, 2020

Study information

• Verified date: February 2021
• Source: The Swedish School of Sport and Health Sciences
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The main aim for this study is to investigate to what extent physical activity of moderate or low intensity, relative to prolonged inactivity, may acutely alter neural activity-related prefrontal cortex oxygenated hemoglobin during a cognitive demanding task in 13- 15 year-old adolescents. The study is primarily focused on investigating these effects in ecologically valid conditions, i.e. activity patterns that closely resemble a typical day in school and using activity modes that are suitable in a school setting.

Description:

The study will be a controlled crossover experimental trial with three conditions. Each participant will complete each of the three experimental conditions, separated by a washout period of minimum four days. Physical activity behaviours and sleep will be monitored the day/night before each test day. The first visit will be a familiarization session for the collection of demographic data, fitness testing, and acquaintance with experimental procedures. On the second, third, and fourth visits, participants will undergo three different standardized 80-minutes interventions in a randomized order. Before and immediately after the 80-minutes interventions, blood pressure, augmentation index, and cerebral hemodynamic response of the prefrontal cortex during standardized cognitive tasks (nback test) will be measured. Additionally, saliva samples will be collected the morning of the test day, and before and after the interventions.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 17
• Est. completion date: December 16, 2020
• Est. primary completion date: December 16, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 13 Years to 14 Years

Eligibility

Exclusion Criteria:

• Ongoing medication that can affect central circulation or brain circulation
• Ongoing infection
• Inability to apprehend information about the study or to perform the tests

Related Conditions & MeSH terms

• Healthy Adolescents

Intervention

Behavioral:
• Prolonged sitting (social breaks)
Participants are required to sit for 80 minutes doing schoolwork, with a toilet break in between. Every twenty minutes participants will have a short social break. Test day begins at 8:00 with pretest measures, followed by the intervention at about 9:00, which will end around 12:00, with subsequent posttest measures.
• Prolonged sitting with step-up exercise break
Participants are required to sit for 80 minutes doing schoolwork, with a toilet break in between. Every twenty minutes participants will have a physical activity break, where they will perform a simple moderate-intensity step-up exercise for three minutes at a predetermined pace. Test day begins at 8:00 with pretest measures, followed by the intervention at about 9:30, which will end around 12:00, with subsequent posttest measures.
• Prolonged sitting with simple resistance activity breaks
Participants are required to sit for 80 minutes doing schoolwork, with a toilet break in between. Every twenty minutes participants will have a physical activity break, where they will perform simple resistance activities following a video for about three minutes. Test day begins at 8:00 with pretest measures, followed by the intervention at about 9:30, which will end around 12:00, with subsequent posttest measures.

Locations

Country	Name	City	State
Sweden	The Swedish School of Sport and Health Sciences (GIH)	Stockholm

Sponsors (7)

Lead Sponsor	Collaborator
The Swedish School of Sport and Health Sciences	COOP, Generation PEP, IKEA, Konsumentföreningen Stockholm, Skandia, The Knowledge Foundation

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in cerebral blood flow	Oxygenated and deoxygenated hemoglobin concentration changes measured with functional near-infrared spectroscopy	before to after 80 minutes intervention
Secondary	Cognitive performance	nback cognitive test (time and accuracy)	before and after 80 minutes intervention
Secondary	Augmentation index	measure of arterial stiffness	before and after 80 minutes intervention
Secondary	Cortisol	measured from saliva	morning; before and after 80 minutes intervention
Secondary	Mood	Positive and Negative Affect Schedule (PANAS) comprised of 20 affect states (10 positive and 10 negative), each affect state scored on a scale going from 1 (very slightly or not at all) to 5 (extremely)	at the beginning of the day; before and after 80 minutes intervention
Secondary	Sleepiness	Karolinska Sleepiness Questionnaire; goes from 1 (extremely alert) to 9 (extremely sleepy)	at the beginning of the day; before and after 80 minutes intervention
Secondary	Alertness	100mm Visual Analogue Scale (VAS); range: 'not at all' to 'completely alert'	at the beginning of the day; before and after 80 minutes intervention