Health, Subjective Clinical Trial
Official title:
Plethysmographic Pulse-contour and Pulse-wave-transit-times for Haemodynamic Evaluation in Bleeding Simulation
The evaluation of haemodynamic changes is still challenging in clinically relevant situations
(e.g. in bleeding, septic and postoperative patients) with the conventional monitoring
routinely used including heart rate and mean arterial pressure. If the arterial pressure
drops and the heart increases, the haemodynamic state is already decompensated and a therapy
is at risk being indicated too late.
Prior to decompensation - still in the state of compensated shock - it would be desirable to
detect the shock already. The compensated shock is characterized by an occult drop of cardiac
output and a hypoperfusion of vital organs like e.g. the splanchnic region. Due to these
pathophysiological characteristics, a therapy would be indicated already in this stadium of
shock progression.
The available monitoring tools to detect compensated shock are on the one hand side invasive
(intravascular catheter), cost-intensive (cost of the catheter systems), or need extensive
training (echocardiography). Consequently, the implementation of advanced haemodynamic
monitoring is still low despite the high clinical relevance for the patients.
It is the goal of this project to evaluate in healthy volunteers the routinely implemented
technology of photo-plethysmography in its ability to detect haemodynamic changes by extended
signal analysis of the pulse-contour and the pulse-wave-transit-times in relation to the
gold-standard echocardiography.
Secondary goal of this study is to analyse the physiological and haemodynamic changes during
progressive central hypovolaemia displayed by non-invasive or minimal-invasive monitoring
devices and associate the changes to each other.
n/a
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