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The Hemodynamics Effect of Glibenclamide on Levcromakalim Assessed by High Resolution Magnetic Resonance Angiography (MRA) Technique in a Randomized Double-blind Cross-over Placebo-controlled Study With Healthy Volunteers

Headache Clinical Trial

Official title:
The Hemodynamics Effect of Levcromakalim After Glibenclamide Administration Assessed by High Resolution MRA Technique in a Randomized, Double-blind, Cross-over and Placebo-controlled Study With Healthy Volunteers.

Clinical Trial Summary

To investigate the effect of levcromakalim/placebo infusion on cranial arteries after glibenclamide administration.

Clinical Trial Description

15 healthy participants will randomly be allocated to receive levcromakalim or placebo on to different days before and after oral glibenclamide administration. The aim of the study is to investigate the effect of levcromakalim/placebo infusion on cranial arteries before and after glibenclamide administration. Repeated magnetic resonance angiography (MRA) measurements covering the middle meningeal artery (MMA), superficial temporal artery (STA) and middle cerebral artery (MCA) before and after glibenclamide administration and levcromakalim/placebo infusion. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03886922
Study type Interventional
Source Danish Headache Center
Contact
Status Recruiting
Phase N/A
Start date April 1, 2019
Completion date August 30, 2023
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