Carbon Monoxide Headache Triggering Properties as Well as Effects on the Brain's Vessels and Blood Flow

Headache Disorders Clinical Trial

Official title:

Carbon Monoxide Headache Triggering Properties as Well as Effects on the Brain's Vessels and Blood Flow

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03385174
• Other study ID #: H-17016387
• Status: Completed
• Phase: N/A
• First received: December 20, 2017
• Last updated: March 12, 2018
• Start date: October 1, 2017
• Est. completion date: March 12, 2018

Study information

• Verified date: March 2018
• Source: Danish Headache Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Studying Carbon monoxide effects on brain vessels in healthy volunteers with magnetic resonance imaging.

Description:

In this study we will systematically investigate the headache-releasing properties of carbon monoxide as well as measure the effect of carbon monoxide on mean blood flow rate in the brain's large vessel with magnetic resonance imaging. These studies are important for understanding and further investigating the carbon monoxide's headache-releasing effect in healthy subjects.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 15
• Est. completion date: March 12, 2018
• Est. primary completion date: February 1, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• Healthy volunteers

• Aged 18-50

• 50-100 kg

Exclusion Criteria:

• Tension type headache more than 5 dage /month

• Other primary headaches

• Daily medication except contraceptives

• Drug taken within 4 times the halflife for the specific drug except contraceptives

• Pregnant or lactating women

• Exposure to radiation within the last year

• Headache within the last 24 hours before start of trial

• Hypertension

• Hypotension

• Respiratory or cardiac disease

• Smoking

• Primary relatives with current or previous migraine

Related Conditions & MeSH terms

• Headache
• Headache Disorders

Intervention

Other:
• Carbon monoxide
Carbon monoxide inhalation

Locations

Country	Name	City	State
Denmark	Danish Headache Center	Glostrup

Sponsors (1)

Lead Sponsor	Collaborator
Danish Headache Center

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in brain blood vessels diameters after a short CO inhalation	To investigate changes in the circumference of intra- and extracerebral blood vessels after inhalation of carbon monoxide using magnetic resonance angiography (MRA).	30 minutes