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Headache Disorders, Secondary clinical trials

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NCT ID: NCT05720819 Completed - Virtual Reality Clinical Trials

Biofeedback-VR for Treatment of Chronic Migraine

Start date: September 9, 2020
Phase: N/A
Study type: Interventional

Migraine is a common, debilitating neurologic condition affecting more than 900 million individuals worldwide. Established treatments for migraine include medications, vitamin and herbal supplements, neuromodulation, and behavioral treatment strategies. This study aims to determine whether a novel, home-based behavioral approach, combined biofeedback-virtual reality therapy, can improve self-reported migraine-related outcomes in individuals living with chronic migraine. In this randomized, controlled pilot study, 50 adults with chronic migraine are randomized to the experimental group (frequent use of a heart rate variability biofeedback-virtual reality device plus standard medical care; n=25) or wait-list control group (standard medical care alone; n=25). The primary outcome is reduction in mean monthly headache days between groups at 12 weeks. Secondary outcomes include mean change in acute analgesic use frequency, depression, migraine-related disability, stress, insomnia, and catastrophizing between groups at 12 weeks. Tertiary outcomes include change in heart rate variability and device-related user experience measures.

NCT ID: NCT05153876 Completed - Migraine Disorders Clinical Trials

An Open Internet-based Survey and Natural Language Processing Project Analysing Written Monologues by Headache Patients

NLPH-OPEN
Start date: October 11, 2021
Phase:
Study type: Observational

Headache disorders are among the most prevalent medical conditions worldwide. The diagnosis of headache disorders is based on medical history taking. Digital solutions such as natural language processing (NLP) may be of aid to understand the linguistic aspects of headache attack and headache related disability descriptions by patients. Participants will provide a written description of their headache disorder. The results will hopefully lead to a better understanding of the potential use of NLP in headache disorders.

NCT ID: NCT04772742 Completed - Migraine Clinical Trials

Eptinezumab in Adults With Migraine and Medication Overuse Headache

Sunlight
Start date: February 17, 2021
Phase: Phase 3
Study type: Interventional

This study evaluates the efficacy of eptinezumab to prevent migraine and headache in patients with the combined diagnosis of migraine and medication overuse headache

NCT ID: NCT04336267 Completed - Chronic Migraine Clinical Trials

Anodal tDCS in Chronic Migraine With Medication Overuse

Start date: January 15, 2015
Phase: N/A
Study type: Interventional

Non-invasive neuromodulation has been applied in several forms of primary headaches, and its usefulness has been suggested for both episodic and chronic migraine (CM). Transcranial direct current stimulation (tDCS) represents a non-invasive electrical stimulation technique that modulates neural brain activity by means of low amplitude direct current trough surface electrodes. Very little evidence is available on the potential effect of tDCS in medication overuse and in the management of medication overuse headache (MOH), a condition frequently associated to CM. CM associated to MOH still represents a challenge for physicians and patients due to the high prevalence in the general population, the associated severe disability, and the high costs imposed by the treatment. The aim of the study was to investigate the possible application of tDCS in the management of CM associated to MOH. The primary objective of this pilot study was therefore to investigate the efficacy of anodal tDCS delivered on the primary motor cortex (M1) as add-on therapy to an in-hospital detoxification protocol in subjects affected by CM and MOH. The secondary objective was to evaluate the possible changes induced by tDCS on conventional EEG in order to obtain further clues about the effects of tDCS on brain activity.

NCT ID: NCT04228809 Completed - Migraine Disorders Clinical Trials

tDCS in Chronic Migraine With Medication Overuse (Edisom)

Edisom
Start date: December 1, 2015
Phase: N/A
Study type: Interventional

Transcranial direct current stimulation (tDCS) was suggested to provide beneficial effects in chronic migraine (CM), a condition often associated with medication overuse (MO) for which no long-term therapy is available.

NCT ID: NCT04091321 Completed - Anesthesia Clinical Trials

Association Between Chronic Headache and Back Pain With Childbirth

Start date: September 13, 2019
Phase:
Study type: Observational

This study uses a single questionnaire to evaluate two separate primary outcomes: 1. To identify association between chronic headache in women who have given birth to children as compared to a control group of women who have raised children but have not given birth to them 2. To identify association between chronic back pain in women who have given birth to children as compared to a control group of women who have raised children but have not given birth to them

NCT ID: NCT04090333 Completed - Migraine Clinical Trials

Endocrinological Profile in Patients With Medication-overuse Headache Before and After Withdrawal Therapy

ENDOMOH
Start date: August 1, 2019
Phase:
Study type: Observational

The project will be conducted to investigate the hormonal homeostasis in men and women, with a special emphasis on sex hormones in men and AMH level in women, before and after withdrawal of the overused analgesics among MOH patients. Additionally, a more broad endocrine profile will be explored before and after withdrawal. It is hypothesized that patients with MOH have disturbed hormone levels, which is normalized after withdrawal of the medication-overuse.

NCT ID: NCT03971071 Completed - Migraine Headache Clinical Trials

A Study to Evaluate the Efficacy and Safety of Erenumab in Adults With Medication Overuse Headache

Start date: October 7, 2019
Phase: Phase 4
Study type: Interventional

Study 20170703 is a phase 4, randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of erenumab against placebo in participants with chronic migraine (CM) who have a history of at least 1 preventive treatment failure and are diagnosed with medication overuse headache (MOH).

NCT ID: NCT03767062 Completed - Clinical trials for Chronic Migraine, Headache

Peripheral Nerve Block and Topiramate in the Treatment of Medication Overuse Headaches

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

Purpose: In this study, the investigators compared the effectiveness of peripheral nerve block (greater occipital nerve block with supratrochlear nerve block) versus topiramate as detoxification therapies in chronic migraine patients with medication overuse headache. Methods: At least ninety chronic migraine patients with medication overuse headache are aimed to include in this study. Patients will be divided into the two groups. The first group will receive topiramate (n=45, estimated) and the second group will receive nerve block (n=45, estimated) as detoxification therapy. Patients' records regarding the visual analog scale (VAS) scores and headache frequencies are aimed to be collected before and after the therapy. Comparisons regarding VAS scores, headache frequencies, 50% responder rates and 75% responder rates will be performed in between topiramate and nerve block groups.

NCT ID: NCT03346252 Completed - Clinical trials for Secondary Headache Disorder

The Effect of Botulinum Toxin A on Headache Attributed to TMD

Start date: May 8, 2017
Phase: Early Phase 1
Study type: Interventional

This study will evaluate the effect of of botulinum toxin on the treatment of Headache Attributed to TMD.