Neem Lotion With Combing for Lice

Status Completed

Clinical Trial Summary

This was a Phase IIa randomised, assessor blinded, parallel group study in which half the participants were treated with Nice 'n Clear neem-based conditioning lotion plus combing with a head louse detection and removal comb and the remainder were treated with Nice 'n Clear plus combing with a normal grooming comb

Clinical Trial Description

Neem oil has had a long reputation for killing a wide range of insects, including head lice. Several products are marketed with this oil as a named active ingredient, e.g. Nice 'n Clear neem-based conditioning lotion. This product was developed as an aid to combing out head lice for eliminating infestation but it has been considered possible that the neem oil could act to kill lice and inhibit their eggs from hatching. This study was designed to compare use of Nice 'n Clear neem-based conditioning lotion when used with two different types of comb. One arm of the study was planned so that participants were combed using a plastic louse detection and removal comb (wet combing with conditioner method), in which it was expected the combing process would play a major role in efficacy. The other arm was planned so that participants were combed using a regular grooming comb, which would normally have little effect for removing head lice from the hair. Comparison of the efficacy outcome in the two groups would determine whether the Nice 'n Clear neem-based conditioning lotion exhibited any effect to eliminate infestation independent of the combing ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02974088
Study type	Interventional
Source	Medical Entomology Centre
Contact
Status	Completed
Phase	Phase 2
Start date	May 2006
Completion date	August 2006

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT00988533` - A Pharmacokinetics (PK) Study in Lice Infested Children 6 Months to 3 Years of Age	Phase 1
Completed	`NCT00672971` - Safety and Efficacy Study to Compare a 4% Dimethicone Foam and Nix Cream Rinse (1% Permethrin) in the Control of Head Lice	N/A
Completed	`NCT00858481` - A Pilot Dose Ranging Study of Spinosad Creme Rinse	Phase 2
Completed	`NCT03301649` - Clinical Endpoint Study of Ivermectin 0.5% Lotion	Phase 3
Completed	`NCT00995124` - Trial of the Ovicidal Activity of Three Head Lice Products (NeutraLice Lotion®, NeutraLice Advance® and Moov Head Lice Solution®) After a Single Application	Phase 4
Completed	`NCT00994422` - Study Comparing the Safety and Efficacy of 0.5% Ivermectin Cream to Placebo in Lice Infested Subjects	Phase 2
Completed	`NCT03337490` - A Clinical Endpoint Bioequivalence Study to Assess Efficacy and Safety of Ivermectin 0.5% Lotion in the Treatment of Head Lice	Phase 3
Completed	`NCT06333054` - Safety and Efficacy of a Head Lice Shampoo	N/A
Completed	`NCT02213055` - Pediatric Head Lice Study Product Comparison	Phase 2
Recruiting	`NCT05379114` - Comparative Study for the Evaluation of a New Medical Device on the Treatment of Head Lice Infestation	N/A
Completed	`NCT03617926` - A Clinical Trial to Evaluate Efficacy and Safety of a Water-soluble Head Lice Product.	N/A
Completed	`NCT01803581` - A Study to Evaluate the Safety and Efficacy of Product X92001327 vs RID Shampoo in Subjects With Head Lice	N/A
Completed	`NCT01068158` - A Study Comparing the Safety and Efficacy of 0.5% Ivermectin Cream to Placebo in Lice Infested Subjects	Phase 3
Completed	`NCT01066585` - A Safety and Efficacy Study Comparing 0.5% Ivermectin Cream to a Vehicle Control in Subjects With Head Lice Infestation	Phase 3
Completed	`NCT00857935` - A Safety and Efficacy Pilot Study Comparing NatrOVA Creme Rinse 1% and NIX Creme Rinse	Phase 2
Completed	`NCT00301340` - Efficacy and Safety of Summers Non-Pesticide Lice Asphyxiator (L.A.)for the Treatment of Head Lice	Phase 3
Completed	`NCT02062073` - Dermal Safety Study to Evaluate the Sensitizing Potential of Abametapir Lotion	Phase 1
Completed	`NCT02061813` - Dermal Safety Study to Evaluate Potential Irritation of Abametapir Lotion	Phase 1
Completed	`NCT00605956` - NatrOVA Photoallergy Study - NatrOVA Creme Rinse in Healthy Volunteers	Phase 1
Completed	`NCT00301327` - Efficacy and Safety of Summers Non-Pesticide Lice Asphyxiator (L.A.)for the Treatment of Head Lice.	Phase 3