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Head and Neck Carcinoma clinical trials

View clinical trials related to Head and Neck Carcinoma.

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NCT ID: NCT06420219 Recruiting - Clinical trials for Head and Neck Carcinoma

An Integrative Multi-Omic Characterization of Head and Neck Carcinogenesis, Progression and Recurrence

Start date: March 25, 2024
Phase:
Study type: Observational

This study evaluates the cell and biomarkers associated with the aggressive behavior of cancer.

NCT ID: NCT06248944 Recruiting - Clinical trials for Head and Neck Carcinoma

AIOCC Italian Registry on Head and Neck Carcinomas

Start date: July 6, 2022
Phase:
Study type: Observational [Patient Registry]

Multicentre, retrospective and prospective observational study aimed to set-up a clinical Italian registry in order to collect information on carcinoma of the Head and Neck.

NCT ID: NCT06183268 Recruiting - Clinical trials for Head and Neck Cancer

Evaluation of Radiobiological Effects in Skin Toxicities Head and Neck Cancer Patients With PBS Proton Therapy

Start date: December 13, 2023
Phase: N/A
Study type: Interventional

This purpose of this study is to examine skin reactions (called radiation dermatitis) that occur during pencil beam scanning (PBS) proton therapy. The researchers will test a unique technique called "Spot Delete" to see if it can reduce skin reactions for head & neck patients treated with PBS. The investigators will also use a special computer model to study how the energy of the proton beam (linear energy transfer) is related to these skin reactions. The study involves creating a treatment plan based on a CT scan, which helps guide the proton beam in the body.

NCT ID: NCT06079697 Recruiting - Clinical trials for Head and Neck Carcinoma

An Exercise Prehabilitation Intervention for Improving Mobility and Recovery Outcomes in Patients Undergoing Head and Neck Cancer Surgery

Start date: February 1, 2024
Phase: N/A
Study type: Interventional

This clinical trial evaluates a prehabilitation exercise intervention for improving mobility and recovery outcomes in patients undergoing surgery for head and neck cancer. Prehabilitation focuses on optimizing health before surgery in order to improve outcomes after surgery. Prehabilitation may include aspects of nutrition, exercise, mental health, or a combination of these. Exercise has been proven to improve anxiety, depression, fatigue, health related quality of life, and physical function among patients undergoing cancer treatment, as well as cancer survivors. The prehabilitation exercise intervention being studied includes a daily walking program, sit-to-stand training, and standing therapeutic exercises before patients undergo surgery. Receiving this prehabilitation exercise intervention prior to surgery may improve mobility and recovery outcomes in patients after surgery for head and neck cancer.

NCT ID: NCT06007092 Recruiting - Clinical trials for Head and Neck Carcinoma

Therapeutic Vaccine in Patients With Human Papillomavirus HPV-positive Oropharyngeal Cancer

HPVDCVax
Start date: July 31, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

This study is a multicentric double-blind placebo-controlled dose escalation trial of a CD40HVac vaccine (humanized anti-CD40 mAb fused to HPV16 E6/E7 oncoproteins) adjuvanted with poly-ICLC (Hiltonol) in patients with HPV16 oropharyngeal carcinoma with no evidence of residual or recurrent disease after surgery and/or radiochemotherapy. The primary objective is to determine the recommended phase 2 dose (RP2D) of a poly-ICLC(Hiltonol)-adjuvanted CD40HVac vaccine according to the safety and the capacity to elicit immune responses of different doses Two dose levels of poly-ICLC-adjuvanted CD40.HVac will be explored - 1st dose level: CD40.HVac 1.0 mg, with 1.0 mg poly-ICLC - 2nd dose level: CD40.HVac 3.0 mg, with 1.0 mg poly-ICLC The safety data will be reviewed by an IDSMB that will give recommendations.

NCT ID: NCT05669430 Recruiting - Clinical trials for Non-small Cell Lung Cancer

A Study of GV20-0251 in Patients With Solid Tumor Malignancies

Start date: March 23, 2023
Phase: Phase 1
Study type: Interventional

This is a Phase 1 study of GV20-0251 being developed for the treatment of participants with advanced solid tumors, who are refractory to approved therapies or other standard of care.

NCT ID: NCT05650034 Recruiting - Clinical trials for Head and Neck Carcinoma

Post-Operative Radiotherapy De-Escalation of Negative Nodal Regions in Head and Neck Squamous Cell Carcinoma

Start date: April 15, 2021
Phase: N/A
Study type: Interventional

This is a non-randomized prospective trial evaluating the non- inferiority of de-escalating the volume and/or dose of elective nodal irradiation in post-operative head and neck squamous cell carcinomas.

NCT ID: NCT05544136 Recruiting - Clinical trials for Head and Neck Cancer

A Study of Decreasing Radiation Therapy and Chemotherapy in People With Head and Neck Cancer

Start date: September 12, 2022
Phase: Phase 2
Study type: Interventional

The purpose of this study is to test the treatment approach of de-escalated radiation and chemotherapy followed by a planned neck dissection surgery in people with head and neck cancer. The study will look at how effective the treatment approach is against participants' cancer.

NCT ID: NCT05526924 Recruiting - Clinical trials for Head and Neck Cancer

Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head and Neck Cancer

Start date: March 7, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety, tolerability and maximum tolerated dose of tislelizumab in combination with pamiparib plus chemoradiotherapy (chemotherapy and radiation) in individuals with recurrent head and neck cancer, which means that the person's cancer has come back after treatment. Participation in the study should last for about 15 months while participants receive tislelizumab and chemoradiotherapy with pamiparib. Afterwards, they will return to the clinic for follow up every 4 months for 2 years, every 6 month for the next 2 years, and then once a year for the rest of their life.

NCT ID: NCT05334069 Recruiting - Melanoma Clinical Trials

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

Start date: August 1, 2022
Phase:
Study type: Observational

This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection. Collecting and storing samples of blood and tissue from patients with and without cancer to study in the laboratory may help researchers develop tests for the early detection of cancers.