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Sparing Parotid Ducts Via MRI Sialography for Reduced Patient Reported Xerostomia

Head and Neck Cancer Clinical Trial

Official title:
Randomized Assessment of Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported Xerostomia Following Radiotherapy for Oropharynx Cancer

Clinical Trial Summary

Radiation-induced xerostomia (dry mouth) is one of the most common and severe toxicities experienced by patients undergoing radiation treatment for head and neck cancer. Radiation-induced dry mouth is a frequently experienced symptom and persists after treatment, potentially indefinitely. Current practice does not specifically attempt to spare the parotid ducts, where stem/progenitor cells are believed to preferentially reside, and considers the entire salivary gland to have equal function. New radiation therapy planning and conducting strategies are needed to reduce this toxicity and maximize patient quality of life post-treatment. This randomized Phase II study explores the contribution of magnetic resonance imaging (MRI) guided salivary gland duct definition to decrease patient-reported xerostomia in patients with oropharynx cancer receiving radiation therapy. The severity of xerostomia will be measured by patient-reported (PRO) symptoms, saliva secretion, saliva pH, and buffering.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06276946
Study type Interventional
Source UNC Lineberger Comprehensive Cancer Center
Contact Melissa Knutsen, MPH
Phone (919) 445-4869
Email melissa_knutsen@med.unc.edu
Status Not yet recruiting
Phase N/A
Start date August 8, 2024
Completion date January 2029
View Details
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