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Clinical Study on the Efficacy of Acetazolamide Combined With Levamisole in the Treatment of HCC

HCC Clinical Trial

Official title:
A Single-center, Single-arm, Open, Prospective, and Exploratory Clinical Study on the Efficacy of Acetazolamide Combined With Levamisole in the Treatment of Advanced HCC

Clinical Trial Summary

The purpose of this study is to evaluate the efficacy and safety of acetazolamide combined with levamisole in the treatment of advanced HCC.

Clinical Trial Description

Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second leading cause of cancer-related deaths in the world. Because HCC is insidious and early diagnosis is difficult, most patients have locally advanced or distant metastasis at the time of diagnosis. So they are not suitable candidates for curative treatments by resection or transplantation. Currently, There are only not more than five drugs to be selected for advanced HCC, although it prolongs the survival for less than 3 months. Recently, metabolomics studies of HCC have shown that typical Warburg effect was observed in hepatoma carcinoma cells. Arginine hydrochloride is a new anticancer drug in the treatment of HCC, which is mainly aimed at the pathway of energy metabolism.acetazolamide may play an anti-tumor role by inhibiting the reverse TCA cycle. The investigators have been proceeding this trial to evaluate the efficacy and safety of acetazolamide combined with levamisole in the treatment of advanced HCC. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04611373
Study type Interventional
Source The First Affiliated Hospital of Zhengzhou University
Contact
Status Recruiting
Phase Phase 3
Start date May 1, 2020
Completion date May 31, 2021
View Details
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