HBV Carrier Clinical Trial
Official title:
Effect of Cyanobacteria Patients With Chronic Hepatitis B Surface Antigen Quantitative Concentration
Hepatocellular carcinoma (HCC) is a very severe disease in Taiwan caused 7,000 deaths per year, and majorly about 70% is caused by the chronic hepatitis B virus infection. A repeat, long-term, and severe chronic hepatitis would be more possible progressed into liver cirrhosis and HCC. As previous records, there might be 2% of chronic HBV patient would progress to liver cirrhosis, and 5% of the liver cirrhosis's patients would develop to HCC. In some cases, the HBV patient also might directly develop to HCC without liver cirrhosis phase.
Hepatocellular carcinoma (HCC) is a very severe disease in Taiwan caused 7,000 deaths per
year, and majorly about 70% is caused by the chronic hepatitis B virus infection. A repeat,
long-term, and severe chronic hepatitis would be more possible progressed into liver
cirrhosis and HCC. As previous records, there might be 2% of chronic HBV patient would
progress to liver cirrhosis, and 5% of the liver cirrhosis's patients would develop to HCC.
In some cases, the HBV patient also might directly develop to HCC without liver cirrhosis
phase.
Spirulina platensis is a kind of ancient livings for a 3.5 billions years, and had been
recognized as a kind of space food by National Aeronautics and Space Administration(USA)
because of containing numerous nutrients, especially vitamin B and beta-carotene.
Beta-carotene would convert into vitamin A and help keep health vision, skin, and mucosa.
With a rich source of vitamins B, especial B12 which is almost only in meals (animal
livers), 1.2 grams of Spirulina platensis daily uptake would be sufficient for a human daily
need, and also be a very good source for vegetarians. The investigators add the B12 test in
this trial as a secondary endpoint to help monitor the absorption rates of the Spirulina
platensis in human. Otherwise, the plant pigments in Spirulina platensis would also have
many bioactivities on human healthy. Among these bio-activities of Spirulina platensis would
contain anti-virus, anti-cancer, immune modulation, anti-inflammation, anti-oxidant, improve
liver abnormality, and liver cirrhosis abilities. As previous small scale of clinical trial
results in HBV patients provided by Far East Bio-Tec Company, lamivudine combined with oral
Spirulina platensis would also improve the sero-conversion rates of HBeAg.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment