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Methotrexate in Erosive Inflammatory Hand Osteoarthritis — MERINO  

Hand Osteoarthritis Clinical Trial

Official title:
The Methotrexate in ERosive INflammatory Osteoarthritis (MERINO) Trial: A Randomized Placebo-controlled Trial to Investigate Clinical Efficacy and Safety of Methotrexate in Erosive Inflammatory Hand Osteoarthritis.

Clinical Trial Summary

A placebo-controlled randomized controlled trial exploring the effect of methotrexate on pain, function and structural outcomes in erosive inflammatory hand osteoarthritis.

Clinical Trial Description

The trial will include Norwegian adult males and females with symptomatic erosive inflammatory hand osteoarthritis. Participants will be randomized 1:1 to either: 1. Methotrexate oral x 1/week; weekly starting dose 15 mg for two weeks, followed by 20 mg the remaining weeks (intervention group). Dosage can be reduced to as low as 10 mg if higher doses are not tolerated. 2. Placebo (control group). Both arms will receive folic acid 1mg daily. The treatment duration for both groups is 52 weeks. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04579848
Study type Interventional
Source Diakonhjemmet Hospital
Contact Ida K. Haugen, MD, PhD
Phone 95859884
Email ida.k.haugen@gmail.com
Status Recruiting
Phase Phase 4
Start date August 12, 2021
Completion date December 31, 2025
View Details
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