Hand Injury — Hand Injury Patients Receiving Different Rehabilitation Programs
Citation(s)
Angeles JG, Heminger H, Mass DP Comparative biomechanical performances of 4-strand core suture repairs for zone II flexor tendon lacerations. J Hand Surg Am. 2002 May;27(3):508-17.
Bunnell S Repair of nerves and tendons of the hand. J Bone Joint Surg 1928; 10:1
Chesney A, Chauhan A, Kattan A, Farrokhyar F, Thoma A Systematic review of flexor tendon rehabilitation protocols in zone II of the hand. Plast Reconstr Surg. 2011 Apr;127(4):1583-92. doi: 10.1097/PRS.0b013e318208d28e. Review.
Duran RJ, House RG Controlled passive motion following flexor tendon repairs in zone 2and 3. In: American Academy of Orthopedic Surgeons: Symposium on Tendon Surgery in the Hand. St. Louis : CV Mosby Co.; 1975
Elliot D Primary flexor tendon repair--operative repair, pulley management and rehabilitation. J Hand Surg Br. 2002 Dec;27(6):507-13.
Evans RB, Thompson DE The application of force to the healing tendon. J Hand Ther. 1993 Oct-Dec;6(4):266-84. Review.
Mandeville JB, Rosen BR Functional MRI. In: Toga AW, MazziottaJC, editors. Brain mapping: the methods. 2nd ed. New York: Academic; 2002. p. 315-49
McLarney E, Hoffman H, Wolfe SW Biomechanical analysis of the cruciate four-strand flexor tendon repair. J Hand Surg Am. 1999 Mar;24(2):295-301.
Rudin M, Mueggler T, Allegrini PR, Baumann D, Rausch M Characterization of CNS disorders and evaluation of therapy using structural and functional MRI. Anal Bioanal Chem. 2003 Nov;377(6):973-81. Epub 2003 Aug 26. Review.
Sirotakova M, Elliot D Early active mobilization of primary repairs of the flexor pollicis longus tendon with two Kessler two-strand core sutures and a strengthened circumferential suture. J Hand Surg Br. 2004 Dec;29(6):531-5.
Strickland JW Flexor tendon injuries. Part 1. Anatomy, physiology, biomechanics, healing, and adhesion formation around a repaired tendon. Orthop Rev. 1986 Oct;15(10):632-45. Review.
Tang JB Clinical outcomes associated with flexor tendon repair. Hand Clin. 2005 May;21(2):199-210. Review.
Tang JB Indications, methods, postoperative motion and outcome evaluation of primary flexor tendon repairs in Zone 2. J Hand Surg Eur Vol. 2007 Apr;32(2):118-29. Epub 2007 Feb 12.
Trumble TE, Vedder NB, Seiler JG 3rd, Hanel DP, Diao E, Pettrone S Zone-II flexor tendon repair: a randomized prospective trial of active place-and-hold therapy compared with passive motion therapy. J Bone Joint Surg Am. 2010 Jun;92(6):1381-9. doi: 10.2106/JBJS.H.00927.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
