A Study to Investigate Nicotinic Acid on VEGFR Inhibitor-Associated

Clinical Trial Summary

Hand-Foot Skin Reaction (HFSR) is a common adverse event induced by Vascular Endothelial Growth Receptor Inhibitor (VEGFRi) in cancer patients. The main purpose of this study is to evaluate the efficacy and safety of nicotinic acid in solid tumor patients with grade II/III VEGFRi-associated HFSR.

See also
	Status	Clinical Trial	Phase
	Active, not recruiting	`NCT04088318` - A Study to Investigate OQL011 on VEGFR Inhibitor-Associated Hand-Foot Skin Reaction in Cancer Patients	Phase 2
	Terminated	`NCT04071756` - Topical Tazarotene Vs Placebo In Hand-Foot-Skin Reactions	Phase 2

See also

Status

Clinical Trial

Phase

Active, not recruiting

NCT04088318 - A Study to Investigate OQL011 on VEGFR Inhibitor-Associated Hand-Foot Skin Reaction in Cancer Patients

Phase 2

Terminated

NCT04071756 - Topical Tazarotene Vs Placebo In Hand-Foot-Skin Reactions

Phase 2

Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.

Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.

Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

NCT number	NCT04242927
Study type	Interventional
Source	First People's Hospital of Hangzhou
Contact	Xueqin Chen, MD
Phone	+8613735430109
Email	chenlucy1437@aliyun.com
Status	Recruiting
Phase	Phase 2
Start date	March 9, 2020
Completion date	March 9, 2022

A Study to Investigate Nicotinic Acid on VEGFR Inhibitor-Associated Hand-Foot Skin Reactions

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms