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Hamartoma Syndrome, Multiple clinical trials

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NCT ID: NCT06080165 Not yet recruiting - Clinical trials for PTEN Hamartoma Tumor Syndrome

Sirolimus for Improving Social Abilities in People With PTEN Germline Mutations

Start date: July 2024
Phase: Phase 1/Phase 2
Study type: Interventional

The goal of this study is to examine the safety and treatment effects of sirolimus for targeting social communication deficits in people with genetic disorders associated with PTEN germline mutations, which are often referred to as PTEN Harmartoma Tumor Syndrome (PHTS). The mechanism of sirolimus in the body has shown promise for helping to improve social communication skills in case reports of people with PHTS. Everolimus, a closely related compound, also showed benefits in social communication skills in a previous pilot trial in people with PHTS. This is a 6 month double-blind trial followed by at 6 month open label extension trial.

NCT ID: NCT03630523 Not yet recruiting - Clinical trials for PTEN Hamartoma Tumor Syndrome

Response of Immune System to Flu Vaccination in PHTS

RIPS
Start date: October 2018
Phase: N/A
Study type: Interventional

this study evaluates the cellular and humoral immune response to seasonal influenze vaccination in PTEN Hamartoma Tumor Syndrome. All subjects will be administered flu vaccination, half of the subjects will be control subjects.