Haemorrhage Clinical Trial
Official title:
Underwater Endoscopic Mucosal Resection Versus Metal Clips With Hot Snare Polypectomy for Resection of Big Pedunculated Colorectal Polyps:a Randomized Controlled Trial
Verified date | October 2023 |
Source | Ningbo No. 1 Hospital |
Contact | Lei Xu |
Phone | +8613486659126 |
xulei22[@]163.com | |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Endoscopic resection of pedicled polyps mainly focuses on how to prevent bleeding, and also needs to pay attention to the convenience of resection and the integrity of resection, which means that different endoscopic resection strategies should be adopted for pedicled polyps with different pedicle sizes. The head larger than 20mm or pedicle larger than 5mm are defined as large pedicle polyps, which are at greater risk of bleeding. Current guidelines recommend hot removal by snare following preoperative saline injection, ligation of the pedicle with a nylon ring or metal clip, depending on the size of the polyp head and pedicle. However, the use of snares and metal clamps does not appear to reduce delayed postoperative bleeding, and the technical requirements of nylon ligation are relatively high. Recent studies have found that Underwater endoscopic mucosal resection (UEMR) is also safe and effective for the treatment of large and medium colorectal stemless polyps. Therefore, it is still necessary to further explore new safe and effective endoscopic resection strategies and techniques.
Status | Recruiting |
Enrollment | 156 |
Est. completion date | August 31, 2026 |
Est. primary completion date | August 31, 2026 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility | Inclusion Criteria: - 1. Patients undergoing endoscopic resection of small and medium pedicled polyps in the First Affiliated Hospital of Ningbo University from October 2023 to August 2026; 2. Age 18-75 years old; 3. Patients who voluntarily agreed to participate in this study and signed informed consent. Exclusion Criteria: - 1. Persons under 18 years of age 2. Persons unwilling or unable to provide informed consent 3. Treatment or radiotherapy for malignant diseases, severe chronic heart or lung diseases, coronary or cerebrovascular events requiring hospitalization within the last 3 months 4.Malignant polyps have infiltrated the pedicle 5. Abdominal symptoms such as severe abdominal pain, abdominal distension, and nausea 6.Patients with inadequate intestinal preparation 7. Patients with lifelong anticoagulant therapy or severe bleeding diseases, patients who have recently taken anticoagulant drugs or antiplatelet drugs (within 1 week) 8.Pregnant or lactating |
Country | Name | City | State |
---|---|---|---|
China | Ningbo first hospital | Ningbo | Zhejiang |
Lead Sponsor | Collaborator |
---|---|
Ningbo No. 1 Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Immediate perforation rate | perforation | 30 seconds | |
Primary | Prevalence of immediate bleeding | Immediate bleeding was defined as an intraoperative bleeding immediately after polypectomy. Level 2, Level 1 was defined as continuous exudation for 1 minute, and level 2 was defined as active blood spray | 1 Minutes | |
Secondary | delayed hemorrhage | Any symptoms of gastrointestinal bleeding (e. g. hematochezia) occurred within 30 days after polypectomy and were classified as mild or severe according on the severity of the bleeding | 2 weeks and 4 weeks |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02203968 -
Fibrinogen in the Initial Resuscitation of Severe Trauma (FiiRST)
|
Phase 1/Phase 2 | |
Recruiting |
NCT06097650 -
Cold Snare Polypectomy Versus Hot Snare Polypectomy for Resection of Small Pedunculated Colorectal Polyps:a Randomized Controlled Trial
|
N/A | |
Completed |
NCT01938768 -
Effects of an Early Prehospital Administration of Tranexamic Acid on Hyperfibrinolysis in Multiple Trauma
|
N/A | |
Completed |
NCT02765022 -
Clip Closure of Mucosal Defects After Endoscopic Mucosal Resection.
|
N/A | |
Completed |
NCT01629381 -
Efficacy of RIvaroxaban for Prevention of Venous Thromboembolism After Knee Arthroscopy
|
Phase 2 | |
Terminated |
NCT01961804 -
PREVACT : Preventive REversal of Vitamine K Antagonist in Minor Craniocerebral Trauma
|
Phase 3 | |
Completed |
NCT02106000 -
A Non-investigational Product (IP) Study to Investigate Lung Function in Women in the Third Stage of Labour
|
N/A | |
Completed |
NCT02480556 -
Comparing Blood Loss During Caesarean Section Between Manual Separation of Placenta & Conservative Management
|
N/A | |
Completed |
NCT02344069 -
Pilot Randomized Trial of Fibrinogen in Trauma Haemorrhage
|
Phase 2 | |
Completed |
NCT00440401 -
TachoSil® Versus Standard Haemostatic Treatment of Haemorrhage in Cardiovascular Surgery (TC-023-IM)
|
Phase 4 | |
Completed |
NCT02745041 -
Fibrinogen Early In Severe Trauma studY
|
Phase 2 |