Haemophilus Influenzae Type B Clinical Trial
Official title:
A Demonstration Project for the Elimination of Haemophilus Influenzae Type B in Three Rural Alaska Native Villages
Hib disease rates in rural Alaska before introduction of HIb conjugate vaccine were among
the highest in the world. Since vaccine introduction, rates have fallen by 90% but the
disease has not been eliminated. This study is designed to test one possible means of
eliminating Hib carriage and thus to eliminate person to person transmission and invasive
disease.
The objective of this study is to evaluate the effectiveness of community-wide use of Hib
conjugate vaccine for eliminating oropharyngeal Hib carriage in rural Alaska villages.
Secondary objectives include:
- Determine risk factors for Hib OP carriage including demographic characteristics, and
immunologic characteristics (antibody level and function). This will be accomplished
through a case-control study described below.
- Measure antibody response to Hib conjugate vaccine among adults who have not previously
received Hib vaccine. This will be accomplished through a cohort study of participating
adults in the vaccine intervention communities.
This was a pilot intervention to assess the feasibility of using Hib conjugate vaccine to eliminate Hib carriage in rural Alaska villages, with three villages to serve as a comparison group. WE performed community-wide surveys of Hib carriage by recruiting volunteers for throat cultures to establish a baseline rate of Hib carriage for each community. Then Hib carriers were offered chemoprophylaxis to clear Hib from their throats. In the vaccine intervention communities, a single dose of Hib conjugate vaccine was offered to persons of all ages. This was followed by a second community-wide Hib carriage survey after one year to assess the effectiveness of the intervention. ;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
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