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AGuIX Gadolinium-based Nanoparticles in Combination With Chemoradiation and Brachytherapy — NANOCOL  

Gynecologic Cancer Clinical Trial

Official title:
Phase I Study of AGuIX Gadolinium-based Nanoparticles in Combination With Chemoradiation and Brachytherapy in Locally Advanced Cervical Cancer

Clinical Trial Summary

This is a phase 1 clinical trial evaluating the safety, tolerability of escalating doses of AGuIX-NP in combination with radiation and cisplatin in patients with locally advanced cervical cancer. Dose escalation will be conducted using the modified toxicity probability interval (mTPI) method. Three dose levels of intravenous AGuIX nanoparticles will be explored: 20mg/kg (level -1), 30 mg/kg (level 1) and 50 mg/kg (level 2).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03308604
Study type Interventional
Source Gustave Roussy, Cancer Campus, Grand Paris
Contact Cyrus CHARGARI, MD
Phone +33 (0) 1 42 11 42 11
Email cyrus.chargari@gustaveroussy.fr
Status Recruiting
Phase Phase 1
Start date May 17, 2018
Completion date May 2024
View Details
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