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Establishment of Individualized Immunotherapy Strategy and Platform Based on Changes of Intestinal Microbiota

Gut Microbiota Clinical Trial

Official title:
Establishment of Individualized Immunotherapy Strategy and Platform for Upper Gastrointestinal Cancer Based on Changes of Intestinal Microbiota

Clinical Trial Summary

To explore and analyze the relationship between intestinal flora changes and the efficacy of individualized immunotherapy in patients with upper gastrointestinal cancer, and to find new biomarkers to predict the efficacy of immunotherapy, bringing new breakthroughs in tumor diagnosis and treatment.

Clinical Trial Description

1. Compare the composition of intestinal flora of patients before and after immunotherapy and in patients with different therapeutic effects of immunotherapy. 2. Combine the results above with the patient's blood sample, which is carried out from the metabolic level. 3. Combine the pathological data of the patient to determine the staging and pathological types, and use blood samples to detect metabolites to find out different metabolites. 4. the metabolic data and the flora data are associated with the analysis to find the bacteria species with higher correlation with the differential metabolites to guide the subsequent animal experiments. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05065515
Study type Observational
Source Xijing Hospital
Contact Jianjun Yang, Dr
Phone 0086-13572533693
Email jianjunyang66@hotmail.com
Status Recruiting
Phase
Start date October 1, 2021
Completion date December 2023
View Details
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