Gut Microbiota Clinical Trial
Official title:
Interaction of Orally Administered Lactobacillus Rhamnosus GG With Skin and Gut Microbiota and Humoral Immunity in Infants With Atopic Dermatitis
Hypothesis: Probiotics have been used as novel adjunct therapeutic approach in atopic
dermatitis. In addition to balancing the gut microecology and promoting host immune
defences, specific probiotics might further aid in controlling the microbial colonization of
the skin, thereby reducing proneness to secondary infections which typically cause sustained
symptoms.
Thirty-nine infants with atopic dermatitis,randomized for a three-month-period in a
double-blind design to receive extensively hydrolysed casein formula (NutramigenR,
Mead-Johnson, USA) supplemented with (n=19) or without (n=20) Lactobacillus rhamnosus GG
(ATCC 53103) 5.0 x 107 cfu/g to achieve a daily intake of 3.4 x 109 cfu.
Sampling (blood and faecal samples, cotton swab from the skin) and clinical examination of
the infant, including SCORAD assessment to determine the severity of atopic dermatitis, at
each study visit (at entry and one month and three months thereafter).
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Caregiver, Investigator), Primary Purpose: Treatment
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