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Glutathione vs. Curcumin Clinical Trial — Glutathione  

Gulf War Syndrome Clinical Trial

Official title:
Testing the Model: A Phase I/II Randomized Double Blind Placebo Control Trial of Targeted Therapeutics: Liposomal Glutathione and Curcumin

Clinical Trial Summary

The investigator proposes to perform a phase I/II study comparing two nutraceuticals and placebo that target mediators identified in the investigator's prior dynamic modeling study of Gulf War Illness (GWI). The investigator will repeat the dynamic modeling before treatment and on therapy to assess the modeling and the impact of the interventions on the homeostatic networks that have identified, with an added focus on the glutathione/redox system.

Clinical Trial Description

In the Investigator's prior study "Dynamic Modeling in GWI", the investigator used an exercise stress model (rest, peak oxygen consumption oxygen uptake, and 7 follow-up sampling points) to measure the mediators of relapse in the context of their interactive homeostatic networks. The investigator surveyed the response of genes and blood-borne biomarkers in order to interrogate and map regulation of neuro-endocrine-autonomic-immune function in these subjects as compared to GW era sedentary healthy controls. The investigator's research team applied an integrative systems-based approach rooted in computational biology connecting gene expression and biomarkers to pathways and to symptoms in order to identify potential therapeutic targets as well as optimal strategies for manipulation of these targets. Using this data the investigator's research team has developed a virtual model of the illness, which has been used to identify potential therapeutic targets. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02848417
Study type Interventional
Source South Florida Veterans Affairs Foundation for Research and Education
Contact Fanny V Collado, RN
Phone 305-575-7000
Email fanny.collado@va.gov
Status Recruiting
Phase Phase 1/Phase 2
Start date April 2016
Completion date August 2020
View Details
See also
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