Curcean AD, Rusu GM, Dudea SM Ultrasound appearance of peripheral nerves in the neck: vagus, hypoglossal and greater auricular. Med Pharm Rep. 2020 Jan;93(1):39-46. doi: 10.15386/mpr-1273. Epub 2020 Jan 31.
Guven SC, Bilgin E, Ozcakar L Ultrasound imaging of the accessory nerve injury in a patient with thrombotic thrombocytopenic purpura and polyneuropathy. Am J Phys Med Rehabil. 2014 Oct;93(10):928. doi: 10.1097/PHM.0000000000000130. No abstract available.
Wilder-Smith EP Swollen nerves slimming: Sequential nerve ultrasound in acute Guillain-Barre syndrome. Clin Neurophysiol. 2016 Feb;127(2):1013-1014. doi: 10.1016/j.clinph.2015.07.010. Epub 2015 Jul 17. No abstract available.
Predictive Value of Neuromuscular Ultrasound of Cranial Nerves in Guillain-Barré Syndrome
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
