Growth Clinical Trial
Official title:
Role of Anabolic Steroid and Propranolol in Paediatric Burn- A Randomized Controlled Trial
propranolol and anabolic steroids have a role in pediatric burn patients and their combined effects are to be studied here. They decrease the catabolic response to burn trauma and minimize the duration of growth arrest hence improving the outcome
Status | Recruiting |
Enrollment | 114 |
Est. completion date | September 28, 2023 |
Est. primary completion date | September 28, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 2 Years to 12 Years |
Eligibility | Inclusion Criteria: - Patients presenting within 48 hours of burn - more than 20% and less than 40 %of TBSA burn (measured via modified rule of nine for pediatric burn according to age) - age 2-12 years (as safety of anabolic steroids is not established in <2years of age) - Scald and flame burn Exclusion Criteria: - Diabetics (diagnosed before hospital admission) - Renal disease (diagnosed before hospital admission) - Asthmatics (on medication previously) - Cardiac anomalies (previously diagnosed) - Patients requiring cardiac support (norepinephrine, dobutamine at any dose and dopamine >7ug/kg). - All 4 limbs burnt |
Country | Name | City | State |
---|---|---|---|
Pakistan | King Edward Medical University, Mayo Hospital | Lahore | Punjab |
Lead Sponsor | Collaborator |
---|---|
King Edward Medical University |
Pakistan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | reversal of growth arrest | BMI in kg/m^2 | at 1 year after burn | |
Primary | Bone mineral density measure | Bone mineral density as g/cm^2 (Z-score) | at 1 year | |
Secondary | no of blood transfusions | number of blood transfusions during hospital stay | at 60 days |
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