Growth Retardation Clinical Trial
Official title:
Nutritional Care Influences Head Growth at Discharge in Extremely Low Birth Weight Infants.
As extremely low birth weight infants are high-risk patients, the study aimed to compare
neonatal care, nutritional strategy and postnatal growth of these infants in two European
neonatal units. A retrospective study included extremely low birth weight infants born in
Lyon, France or in Stockholm, Sweden. Data on morbidity, treatments, care practices,
macro-nutrient intakes and postnatal growth were collected to determine risk factors of extra
uterine growth restriction at discharge.
By comparing postnatal growth in ELBW infants hospitalized in two European neonatal intensive
care units with different nutritional and extra nutritional care,our objective was to
evaluate the role of nutrition in this population of preterm infants.
In a retrospective study, all ELBW infants (birth weight under 1000 g) with a gestational age
between 23 and 28 weeks were included if they were admitted during the first 24 hours of life
and stayed for at least seven weeks in two European units (Lyon, france, and Stockholm,
Sweden). Parenteral and enteral nutrition policies were detailed and protein and energy
intakes were collected.Growth assessment Postnatal growth was precisely evaluated and
compared in the two groups of infants.
Body weight, crown-heel length and head circumference were measured in both units at birth
and until discharge. We calculated z-scores and changes in z-scores between birth and 36
weeks post-conceptional age (delta z-score) for body weight, HC, and crown-to-heel length
using Olsen's references. Intra-uterine growth restriction was defined as a birth weight
below or equal to minus two standard deviations. Extra-uterine growth restriction was defined
as a z-score loss above or equal one standard deviation between birth and 36 weeks PCA. I
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