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Use of miRNAs in Growth Hormone Deficiency (GHD) — GH-miRNA2  

Growth Hormone Deficiency Clinical Trial

Official title:
New Potential Biomarkers for Diagnosis of Growth Hormone (GH) Deficiency and Early Assessment of Response to GH Treatment for Appropriate Personalization of Therapy

Clinical Trial Summary

This study aims at improving knowledge about the diagnosis of growth hormone deficiency (GHD) and treatment with growth hormone (GH), with the goal of providing information on the presence of new biomarkers, such as miRNAs, for diagnostic and therapeutic purposes, with the goal of establishing a personalized GH treatment scheme, optimizing resources, reducing costs, and improving outcomes.

Clinical Trial Description

In 200 prepubertal and pubertal subjects with the suspicion of GHD, the levels of three specific circulating miRNas will be measured to establish whether they can be used for the diagnosis of GH deficiency. In subjects with isolated idiopathic GHD (IIGHD), short statured patients born SGA, Noonan and Turner syndromes, and SHOX deficiency, we will also assess the changes of the identified miRNAs before and after 3 months on GH therapy to verify an early growth prediction model for growth response at 12 months on treatment. Finally, we plan to identify any differences in these miRNAs at 3 months on treatment using daily GH versus weekly (long-acting) GH. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06455956
Study type Observational
Source University of Parma
Contact Maria E Street, MD, PhD
Phone +39 0521 033557
Email mariaelisabeth.street@unipr.it
Status Recruiting
Phase
Start date April 13, 2023
Completion date March 1, 2026
View Details
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