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Growth and Asymmetric diMethylArginine — GAMMA  

Growth Hormone Deficiency Clinical Trial

Official title:
Validation of the Dosage of Asymmetric Dimethylarginine (ADMA) Plasma in the Assessment of Endothelial Dysfunction During Growth Hormone Deficiency and Intrauterine Growth Retardation

Clinical Trial Summary

Principal objective : Validation of a handy biochemical parameter, plasma concentration of Asymmetric DimethylArginine (ADMA), based on a recognize biochemical parameter, the dilation of the brachial artery, at ultrasound examination, after the deflation of a cushion to evaluate artery dysfunction (vascular suffering) in growth diseases, growth hormone deficiency (GHD) and intrauterine growth retardation (IUGR)

Secondary objectives:

- Comparison of ADMA plasma concentrations with dose of matched healthy control children

- Investigation of the mechanisms of arterial dysfunction, inflammation, oxidative stress and insulin resistance.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03422081
Study type Observational
Source University Hospital, Lille
Contact
Status Active, not recruiting
Phase
Start date June 2014
Completion date December 2020
View Details
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