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D-vitamin And Graves' Disease; Morbidity And Relapse Reduction — DAGMAR  

Graves' Disease Clinical Trial

Official title:
The DAGMAR Study. D-vitamin And Graves' Disease; Morbidity And Relapse Reduction: A Randomised, Clinical Trial.

Clinical Trial Summary

The purpose of this study is to investigate the effects of vitamin D supplementation on morbidity and risk of relapse in patients with Graves' disease.

Clinical Trial Description

In a multicentre trial, 260 patients with newly diagnosed Graves ' disease will be randomized to cholecalciferol 70 mcg/day or placebo in a parallel Group design. Drop outs prior to 31th of December 2017 will be replaced. The intervention will continue during treatment with antithyroid drugs (ATD), and for a period of 12 months after cessation of ATD. Blood samples will be collected at study entry, at 3 and 9 months, and at end of study. QoL questionnaires on nine occasions through out the study period. In a subcohort of 80 participants detailed examinations of bone density and geometry, muscle strength and postural balance, immune tests (N=50), and measurements of arterial stiffness will be performed at study entry, and at 3 and 9 months after randomisation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02384668
Study type Interventional
Source University of Aarhus
Contact
Status Completed
Phase N/A
Start date March 24, 2015
Completion date December 2020
View Details
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