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Cyclophosphamide, Abatacept, and Tacrolimus for the Prevention of GvHD

Graft Vs Host Disease Clinical Trial

Official title:
Phase II Single-Arm Open-Label Study Of Reduced-Dose Post-Transplant Cyclophosphamide, Abatacept, and Short-Duration Tacrolimus for the Prevention of Graft-Versus-Host Disease (GVHD) Following Haploidentical Hematopoietic Stem Cell Transplantation (HSCT)

Clinical Trial Summary

This is a single arm, open label, phase II clinical trial. Adult patients with hematological malignancies undergoing allogeneic HSCT from first- or second-degree haploidentical donor are eligible for the study if they meet the standard criteria defined in our institutional standard operation procedures (SOPs), meet all inclusion criteria, and do not satisfy any exclusion criteria. Patients will receive non-myeloablative, reduced-intensity or myeloablative conditioning regimen followed by peripheral blood hematopoietic stem cells. Patients will receive dosed reduced cyclophosphamide, abatacept, and short-duration tacrolimus for GvHD prophylaxis.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05621759
Study type Interventional
Source NYU Langone Health
Contact Emma Futamura
Phone 212-731-6217
Email Emma.Futamura@nyulangone.org
Status Recruiting
Phase Phase 2
Start date August 23, 2022
Completion date August 23, 2026
View Details
See also
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