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Trial of Filgrastim Versus Placebo Following Allogeneic Bone Marrow Transplantation

Graft vs Host Disease Clinical Trial

Official title:
Randomized Trial of Filgrastim Versus Placebo Following Allogeneic Bone Marrow Transplantation

Clinical Trial Summary

The effect of haematopoietic growth factors on neutrophil recovery after allogeneic bone marrow transplantation is well recognized. Recent laboratory studies demonstrated that these cytokines may also modify T-cell and dendritic cell function, but whether the effect is strong enough to alter the risk of graft-versus-host disease (GvHD) is unclear.

The aim of this randomised study is to determine the effect of granulocyte colony-stimulating factor [G-CSF] (Neupogen; filgrastim) on the risk of acute GvHD after allogeneic bone marrow transplantation.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00207792
Study type Interventional
Source Centre National de Greffe de Moelle Osseuse
Contact Tarek Ben Othman, MD
Phone 98901456
Email benothman-t@mailcity.com
Status Recruiting
Phase Phase 3
Start date July 2005
View Details
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