Graft Rejection Clinical Trial
Official title:
Study of the Pathogenicity and Humoral Immune Response Induced by BK Virus in Lung Transplant Recipients
BK virus (BKV) is a ubiquitous virus that infects more than 80% of the population. In case of
immunosuppression, BKV can replicate and induce nephropathies in renal transplant recipients
or haemorrhagic cystitis in bone marrow transplant recipients. The disruption of the balance
between BKV replication and immune control is considered the key element in the development
of these pathologies. During lung transplantation, patients undergo intense immunosuppression
that favors the reactivation of persistent viruses such as EBV, CMV and probably BKV.
Although the data on EBV and CMV reactivation are very clear and allow optimal management,
the prevalence of BKV replication and its clinical impact in lung transplant recipients
remains unknown at this time.
The aim of this study is to know the incidence and clinical impact of BKV replication in lung
transplant recipients. Moreover, the results will help to better understand the interaction
between the virus and his host, with a focus on the humoral and cellular immune response
against BKV. The results could possibly enable to define predictive markers of BKV
replication and of its evolution.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00771875 -
Randomized Trial for Mixed Acute Rejection
|
Phase 2 | |
| Completed |
NCT00369382 -
Study Of The Safety And Efficacy Of Conversion From A CNI To Sirolimus In Renally-Impaired Heart Transplant Recipients
|
Phase 4 | |
| Completed |
NCT01009619 -
Azithromycin in Bronchiolitis Obliterans Syndrome
|
Phase 4 | |
| Not yet recruiting |
NCT05072951 -
Urine Biomarker for Kidney Transplant Rejection
|
||
| Completed |
NCT01211509 -
Montelukast in Bronchiolitis Obliterans Syndrome
|
Phase 4 | |
| Recruiting |
NCT01066689 -
Impact of Treatment With Rituximab on the Progression of Humoral Acute Rejection After Renal Transplantation
|
Phase 3 | |
| Completed |
NCT00251004 -
Efficacy and Safety Study of Everolimus Plus Reduced Cyclosporine Versus Mycophenolic Acid Plus Cyclosporine in Kidney Transplant Recipients
|
Phase 3 | |
| Completed |
NCT00254709 -
Study Evaluating Two Different Sirolimus-based Immunosuppressive Regimens in Elderly Kidney Transplant Recipients
|
Phase 4 | |
| Recruiting |
NCT04851145 -
Mass Spectrometry-based Proteomics in Microvascular Inflammation Diagnosis in Kidney Transplantation.
|
N/A | |
| Completed |
NCT00001984 -
Effectiveness of the Investigational Drug Campath-1H in Preventing Rejection of Transplanted Kidneys
|
Phase 2 | |
| Completed |
NCT04488094 -
Diagnostic Validity of [18F]FSPG PET for the Assessment of Acute Rejection After Heart or Liver Transplantation
|
Phase 2 | |
| Not yet recruiting |
NCT03147157 -
The Effect of Human Leukocyte Antigen Macthing on Guiding Tacrolimus Regimen After Liver Transplantation
|
N/A | |
| Completed |
NCT00761787 -
Cardiac Allograft Rejection Gene Expression Observational (CARGO) II STUDY
|
N/A | |
| Completed |
NCT00000137 -
Collaborative Corneal Transplantation Studies (CCTS)
|
Phase 3 | |
| Completed |
NCT00266123 -
Study Comparing Two Sirolimus Regimens vs. Tacrolimus and Mycophenolate Mofetil Regimen in Kidney Transplant Recipients
|
Phase 4 | |
| Completed |
NCT00035555 -
Study Comparing the Safety and Efficacy of Belatacept With That of Cyclosporine in Patients With a Transplanted Kidney
|
Phase 2 | |
| Completed |
NCT00001858 -
Monitoring for Tolerance to Kidney or Combined Kidney-Pancreas Transplants
|
||
| Completed |
NCT00895583 -
Study Evaluating A Planned Transition From Tacrolimus To Sirolimus In Kidney Transplant Recipients
|
Phase 4 | |
| Completed |
NCT00089947 -
A Study to Evaluate the Effect of Thymoglobulin and Reduced Doses of Steroids to Prevent Renal Transplant Rejection
|
Phase 2 | |
| Enrolling by invitation |
NCT05285878 -
Fingolimod for the Abrogation of Interstitial Fibrosis and Tubular Atrophy Following Kidney Transplantation
|
Phase 2 |