Good Ovarian Response Clinical Trial
Official title:
Evaluation of the Relationship Between Air Bubbles Depth and Pregnancy Rate in ICSI Cycles
The aim of this work is to assess the effect of air bubbles localization inside the uterus
on embryo transfer outcome in ICSI cycles.
Is there a relationship between embryo transfer outcome and the distance between fundal
endometrial surface and air bubbles assessed by trans-abdominal ultrasound?
All ET will be performed on day 3 after oocyte retrieval at the blastocyst stage by one
operator under trans-abdominal US guidance performed by one physician, without any
anesthesia or sedation with moderate bladder filling. Two embryos will be transferred using
the same type of catheter which is Labotect embryo transfer catheter. It's a semirigid
catheter that's less likely to induce endometrial trauma and uterine contractions.
The tip of the inner catheter will be placed approximately 1.5-2 cm from the fundal
endometrial surface.The distance between the fundal endometrial surface and air bubbles will
be measured and categorized as:
- Group 1: air bubbles depth <10 mm.
- Group 2: air bubbles depth >10 mm. The primary outcome will be biochemical pregnancy
rate based on serum quantitative beta-hCG level at 14 days after ET. Secondary outcome
will be clinical pregnancy rate using trans-vaginal US examination at 6 - 8 weeks of
amenorrhea to detect the presence of fetal sac & pulsation.
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Observational Model: Case Control, Time Perspective: Prospective