Gonorrhea Clinical Trial
Official title:
Antimicrobial Susceptibility Patterns of Neisseria Gonorrhea Isolates in an Era of Quinolone Resistance
To perform a laboratory sensitivity testing survey of antibiotic agents against Neisseria gonorrhea isolates from men with symptomatic urethritis seen at an STD clinic.
Until recently, the fluoroquinolones (ofloxacin, ciprofloxacin, levofloxacin) have been the
first line oral agents for the empiric treatment of gonorrhea. The prevalence of quinolone
resistant Neisseria gonorrheae (QRNG) has been rising since 2000. In 2006, the CDC updated
its guidelines to include recommendations against the use of quinolones for treatment of
Neisseria gonorrheae. Ceftriaxone (available only by intravenous or intramuscular route) was
named as the first line treatment for urogenital and pharyngeal disease. Availability, in
the United States, of the other two CDC recommended agents cefixime (oral) and spectinomycin
(IM) has been nonexistent.
At this time, there is little data on the in-vitro (laboratory test) susceptibility of
antibiotics against gonorrhea, particularly oral drugs. The purpose of this study is to
collect specimens of gonorrhea in a non-invasive swab manner from men with symptomatic
urethral discharges for laboratory sensitivity testing against a wide array of antibiotic
agents.
Specific Aims:
To perform a laboratory sensitivity testing survey of antibiotic agents against Neisseria
gonorrhea isolates from men with symptomatic urethritis seen at a Duval County STD clinic .
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Observational Model: Case Control, Time Perspective: Prospective
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