Role of Femoral Nerve Block on Prevention of Postoperative Deep Venous Thromboembolism

Gonarthrosis Clinical Trial

Official title: Prevention of Deep Venous Thromboembolism: Effect of Preemptive Analgesic of Femoral Nerve Block in Patients Undergoing Total Knee Arthroplasty

Status Recruiting

Clinical Trial Summary

To investigate whether preemptive analgesic of femoral nerve block could prevent deep venous thromboembolism due to inhibiting the excessive release of neutrophil elastase and inflammatory cytokines.

Clinical Trial Description

Femoral nerve block is an effective analgesic mode in patients after total knee arthroplasty. In recent studies, there has been shown that a large amount of neutrophil elastase release from neutrophils could induce the development of deep venous thromboembolism and femoral nerve block may reduce the incidence of the development of deep venous thromboembolism. In addition, inflammatory cytokines including interleukin-1(IL-1), IL-6, IL-8 and tumor necrosis factor(TNF) were associated with deep venous thromboembolism. Thus, the investigators hypothesised that preemptive analgesic of femoral nerve block could prevent deep venous thromboembolism due to inhibiting the excessive release of neutrophil elastase and inflammatory cytokines. ;

Study Design

Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Gonarthrosis
• Thromboembolism
• Venous Thromboembolism

• NCT number: NCT02411097
• Study type: Interventional
• Source: General Hospital of Ningxia Medical University
• Contact: Xinli Ni
• Phone: +086 951-6743252
• Email: xinlini6@yahoo.com
• Status: Recruiting
• Phase: N/A
• Start date: September 2014
• Completion date: October 2015