Causes of Goiter in Children Attending Assiut University Children Hospital

Goiter Clinical Trial

Official title:

Cases of Goiter in Children Attending Assiut University Children Hospital

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03202160
• Other study ID #: CGCA
• Status: Not yet recruiting
• Phase: N/A
• First received: June 27, 2017
• Last updated: June 27, 2017
• Start date: April 15, 2018
• Est. completion date: September 15, 2019

Study information

• Verified date: June 2017
• Source: Assiut University
• Contact: Hanaa A Mohammed, MD
• Phone: 00201120096055
• Email: hae50[@]hotmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Thyroid disorders are one of the most common endocrine problems in children and adolescents. Diagnostic considerations can be approached from the perspective of the goiter.A goiter, or thyromegaly, is an enlargement of the thyroid gland.Persons with enlarged thyroids can have normal function of the gland (euthyroidism), thyroid deficiency (hypothyroidism), or overproduction of the hormones (hyperthyroidism).

Description:

Congenital goiter most commonly occurs in neonates born to mothers with known thyroid disease especially Graves' disease. Other causes of congenital goitrous hypothyroidism are thyroid dyshormonogenesis, endemic iodine deficiency and maternal goitrogen ingestion or iodine excess (expectorants, povidone iodine).

The most common causes of euthyroid goiter in childhood are chronic lymphocytic thyroiditis and a colloid goiter (simple goiter). Thyroid enlargement that is not caused by inflammatory, infectious or neoplastic causes is termed a colloid goiter, also.

Chronic lymphocytic thyroiditis , also known as Hashimoto thyroiditis, is an autoimmune, inflammatory process that causes up to 55% to 65% of all euthyroid goiters, and almost all cases of thyroiditis in childhood and adolescence. A large North American prevalence study showed that as many as 1.2% of children aged 11 to18 years have chronic lymphocytic thyroiditis, as defined by an enlarged thyroid gland and detectable serum thyroid antibodies.

Thyroid nodules are relatively common in adolescents; these nodules are usually asymptomatic and often discovered incidentally, but they raise the fear of cancer. A multi-nodular goiter is almost invariably caused by Hashimoto's thyroiditis and it carries a good prognosis. The asymptomatic, solitary thyroid nodule is a thyroid adenoma, thyroid carcinoma or a thyroid cyst. Thyroid carcinoma occurs in approximately one per one million persons/year in the first-two decades of life.

No reported data are found as regard of causes of goiter in children in our locality.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 50
• Est. completion date: September 15, 2019
• Est. primary completion date: April 15, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A to 18 Years

Eligibility

Inclusion Criteria:

• Children of both sexes of ages since birth up to 18 years old who are presented by goiter.

Exclusion Criteria:

• Any patient with neck swelling other than goiter.

• Refusal of participation.

Related Conditions & MeSH terms

• Goiter

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (1)

Muirhead S. Diagnostic approach to goitre in children. Paediatr Child Health. 2001 Apr;6(4):195-9. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Serum T3 and T4	Serum T3 and T4 for diagnosis of cause of goiter	1 day
Primary	Neck ultrasonography	Neck ultrasonography for confirmation of diagnosis of goiter and for diagnosis of cause of goiter	1 day