Glucose Control Clinical Trial
Official title:
The Role of Genetic Variation in CLTCL1 and Other Related Genes in Relation to Whole-body Glucose Control: A Pilot Study
Verified date | May 2022 |
Source | University of Bath |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Maintaining stable blood glucose concentrations after eating has important implications for health. Individuals who are better able to maintain stable blood glucose concentrations after consuming carbohydrate have a lower risk of mortality from cardiovascular disease. Muscle is the primary tissue for glucose disposal following a meal, and responsiveness of this tissue to insulin is dictated by GLUT4 translocation to the muscle cell membrane. Clathrin heavy chain isoform 22 (CHC22) is a protein that plays a key role in intracellular GLUT4 action, and it may play an important role in whole-body glucose control. Genetic variation in the gene which codes for CHC22 may be able to explain differences in glucose control at the whole-body level.
Status | Completed |
Enrollment | 82 |
Est. completion date | March 1, 2022 |
Est. primary completion date | February 1, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility | Inclusion Criteria: - Body mass index between 18.5-29.9 kg/m^2 - Aged 18-65 years - Able and willing to provide informed consent and safely comply with study procedures Exclusion Criteria: - Any reported condition or behaviour deemed either to pose undue personal risk to the participant or introduce bias - Any diagnosed metabolic disease (e.g. type 1 or type 2 diabetes) - Any reported use of substances which may pose undue personal risk to the participants or introduce bias into the experiment - Lifestyle not conforming to standard sleep-wake cycle (e.g. shift worker) |
Country | Name | City | State |
---|---|---|---|
United Kingdom | Department for Health, University of Bath | Bath |
Lead Sponsor | Collaborator |
---|---|
Javier Gonzalez | University College, London |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Plasma glucose incremental area under the curve (CHC22 genotype) | Plasma glucose samples will be obtained throughout the 2-hour postprandial period and the incremental area under the curve will be calculated, this will be grouped by CHC22 genotype. | 2 hours | |
Primary | Peak plasma glucose (CHC22 genotype) | Plasma glucose samples will be obtained throughout the 2-hour postprandial period and the peak glucose concentration will be measured, this will be grouped by CHC22 genotype. | 2 hours | |
Secondary | Fasting plasma glucose concentrations (CHC22 genotype) | Plasma glucose will be measured at baseline and will be grouped by CHC22 genotype. | 2 hours | |
Secondary | Plasma glucose incremental area under the curve (other genotypes) | Plasma glucose samples will be obtained throughout the 2-hour postprandial period and the incremental area under the curve will be calculated, this will be grouped by genotyping other genes related to glucose control or sweet taste sensitivity. | 2 hours | |
Secondary | Fasting plasma glucose concentrations (other genotypes) | Plasma glucose will be measured at baseline and will be grouped by genotypes related to glucose control and sweet taste sensitivity. | 2 hours | |
Secondary | Matsuda insulin sensitivity index | Matsuda insulin sensitivity index will be calculated using blood samples collected in the 2-hour postprandial period. | 2 hours | |
Secondary | Homeostasis model of insulin resistance | Homeostasis model of insulin resistance will be calculated using blood samples collected in the 2-hour postprandial period. | 2 hours |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
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