Multicentre Clinical Study to Evaluate the Effect of Personalized Therapy on Patients With Immunoglobulin A Nephropathy.

Glomerulonephritis Clinical Trial

— CLIgAN  

Official title:

Multicentre Prospective Open Label Clinical Study to Evaluate the Effect of Personalized Therapy on Patients With Immunoglobulin A Nephropathy.

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04662723
• Other study ID #: 2
• Status: Recruiting
• Phase: Phase 4
• Start date: May 1, 2023
• Est. completion date: December 31, 2026

Study information

• Verified date: September 2023
• Source: Fondazione Schena
• Contact: Francesco P Schena
• Phone: 3336771291
• Email: paolo.schena[@]uniba.it
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Idiopathic immunoglobulin A nephropathy (IgAN) is the most common biopsy-proven glomerulonephritis in the world. Approximately 40% of IgAN patients reach end-stage kidney disease (ESKD) 20 years after their kidney biopsy. The high prevalence of ESKD suggests the need to move from a generalized therapy for all patients to personalized therapy.

Many RCTs have been conducted stratifying patients based on the laboratory findings (serum creatinine, eGFR and daily proteinuria). In contrast, data from the kidney biopsy has been used only for clinical diagnosis. Therefore, IgAN patients with active or chronic renal lesions have not been equally distributed in experimental and control arms of the randomized clinical trials (RCTs) Our clinical study of IgAN (CLIgAN) is a multicentre, prospective, controlled and open-label randomized clinical trial based on patients' stratification at the time of their kidney biopsy. The investigators will consider, first, the type of renal lesions followed by the serum creatinine values, eGFR and proteinuria. IgAN patients with active renal lesions (n=132) will be enrolled in the first RCT (ACIgAN) in which they will receive corticosteroids (pulse therapy) plus oral corticosteroids combined with RASB or RASB followed by oral corticosteroids. IgAN patients with chronic or moderate renal lesions at high or very high risk of chronic renal disease (n=294) will be enrolled in the second RCT (CHRONIgAN) in which they will receive the SGLT2 inhibitor combined with RASB compared with RASB combined with oral corticosteroids. Using this approach, the investigators hypothesize that patients could receive personalized therapy based on renal lesions to ensure that the right drug gets to the right patient at the right time.

Recently, we developed a Clinical Decision Support System (CDSS) tool using artificial intelligence (artificial neural networks) to identify IgAN patients at high risk of developing ESKD. The IgAN tool (DialCheck) was validated in a retrospective cohort of IgAN patients but not in a prospective clinical study. The investigators propose to measure the power of the DiaCheck tool in patients enrolled in both RCTs to determine whether personalized therapy can slow the decline of the renal function to delay the ESKD.

The CLIgAN study also includes a cutting-edge molecular study for precision therapy (PRECIgAN).

Description:

BACKGROUND AND RATIONALE. Idiopathic Immunoglobulin A nephropathy (IgAN) is the most common biopsy-proven glomerulonephritis in the world. It is more prevalent in Asia than in Europe and the US. Approximately 40% of IgAN patients reach end-stage kidney disease (ESKD) 20 years after their kidney biopsy. The high prevalence of ESKD shows that IgAN has a significant economic impact in the all countries because renal replacement therapy is costly. Moreover, the disease's onset in the second and third decades of life represents a social challenge because young adult patients are very active and highly productive in the workplace. This challenge is one more reason to move from a generalized therapy for all patients to a personalized therapy.

The first edition of the KDIGO guidelines, published in 2012, suggested different therapeutic approaches for IgAN patients based on the clinical setting. However, the KDIGO guidelines do not consider the presence of active (endocapillary and extracapillary lesions) and chronic (tubulointerstitial lesions) renal lesions at the time of the kidney biopsy for therapy decision. The investigators of the clinical study in IgAN patients (CLIgAN) will consider for the patient's stratification the type of renal lesions, preliminarily, and then the clinical parameters as estimated glomerular filtration rate (eGFR) and proteinuria because the categorization of proteinuria and eGFR is not enough for a complete diagnosis of the disease.

AIMS. Considering the critical role of kidney biopsy, in the CLIgAN study the investigators plan to evaluate (i) the effect of corticosteroids combined with RASBs in IgAN patients with active renal lesions (ACIgAN) versus RASBs for 3 months followed by oral corticosteroids to determine whether the renal lesions are reversed by immediate corticosteroid therapy; (ii) the effect of SGLT2i in patients with chronic or moderate renal lesions (CHRONIgAN) to determine whether a delay of the ESKD onset is achieved; (iii) after the prediction of ESKD through the IgAN CDSS tool (DialCheck), to determine whether personalized therapy delays the impairment of the renal function; (iv) finally, on a small cohort of active and chronic IgAN patients enrolled in the CLIgAN study, a cutting edge-molecular study will be conducted to evaluate the effect of precision therapy (PRECIgAN).

STUDY DESIGN. The investigators have designed a prospective, multicentre, open-label clinical study that includes two multicentre randomized controlled trials (RCTs) based on the kidney biopsy report.

In the first RCT, patients with active renal lesions (E1 and/or C1), daily proteinuria >0.5 g and GFR ≥ 30 ml/min/1.72 m2 will be enrolled. They will be randomized to receive corticosteroids combined with RASBs in the experimental arm or RASBs alone in the control arm. Aim of this trial is to demostrate the benefit of corticosteroids in patients with active renal lesions.

In the second RCT, patients with chronic renal lesions (T1,2) and patients with moderate renal lesions (M0,1; S0,1; T0; E0; C0) at high or very high CKD risk (proteinuria> 0.5 g/day and GFR ≥ 30ml/min/1.73 m2) will be enrolled. They will be randomized to receive SGLT2 inhibitor (SGLT2i) combined with RASBs (experimental arm) or RASBs combined with corticosteroids (control arm). Aim of this trial is demostrate the benefit of SGLT2i combined with RASBs.

In conclusion, we have designed two RCTs (i) to study personalized therapy in biopsy-proven IgAN patients and (II) to monitor the outcomes to look at whether personalized therapy may delay the time to reach the ESKD predicted by our IgAN tool.

RECRUITMENT AND FOLLOW-UP. Renal Units will be involved in the enrollment of IgAN patients during a period of three years. The follow-up study to measure the outcomes will consist of regular visits at the prescribed times and to collect clinical and laboratory data and information on drug adherence. At the end of the trial, each patient will receive a final visit in the outpatient section.

OTHER MEAUSURES. Age, body mass index, eradication of infectious foci, or concurrent antibiotic therapy to prevent infections or to avoid the transformation of a trivial infection into a severe complication will be considered. Covid-19 vaccination will be done in all patients who will receive corticosteroids therapy. In addition, home and life conditions and culture will be analyzed. Regular daily exercise to prevent obesity and cardiovascular disease will be prescribed.

Dietary counseling. Patients with CKD stage 1 and 2 will observe the Mediterranean diet combined with reduced intake of proteins (1.0 - 0.8 g/kg bw/day). A reduced intake of proteins (0.6 - 0.8 g/kg bw/day) will also be prescribed to patients with CKD stage 3. Salt intake will be limited to 1.5 g/day. Dietary compliance will be assessed by measuring daily urinary sodium and urea excretion. Physical activity will be observed for 30 min. every day, primarily in the morning.

Severe adverse events. Infections, impaired glucose tolerance, weight gain, hypoglycemia will be monitored during the follow-up.

VARIABLES OF THE DISEASE. Kidney biopsy will be scored according to the Oxford classification because it is a simple method for predicting renal outcomes and for differentiating active and chronic renal lesions. Therefore, the kidney biopsy will be the principal key-note, not only for diagnosis but also for personalized therapy, because active renal lesions will be treated with immediate corticosteroid therapy before lesions become chronic. In some RCTs IgAN patients received six months of RASBs treatment before their enrollment for corticosteroid therapy. In our opinion this approach is not correct because the acute renal lesions evolve in the chronic stage and are no-responsive to corticosteroid therapy. Therefore, the aim of the first RCT is early treatment of the active renal lesions because they are responsible for altered GFR and proteinuria.

The definition of remission or no response of the MESTC lesions to therapy in published studies is inconsistent. Therefore, high-quality clinical trials with a large sample size are necessary to define the response of histological renal lesions to corticosteroids in biopsy-proven IgAN. The kidney biopsy will be analyzed using digital histopathologic analysis coupled with machine-learning tools. At least eight glomeruli will be available for a correct diagnosis. Renal tissue sections will be stained with hematoxylin and eosin, periodic acid-Schiff and methenamine silver. The last edition of the Oxford classification (MESTC) will be used for scoring the renal lesions.

Three independent renal pathologists, blinded to the study results, will score the lesions in the kidney biopsy using the Aperio System. The histology report will be necessary for the enrollment of patients. No larger RCT has confirmed that the disease improves when clinical decisions are made in a short time in the presence of the MESTC score.

• Serum creatinine will be measured using enzymatic methods calibrated to the National Institute of Standards and Technology's (NIST) liquid chromatography isotope dilution mass spectrometry method. eGFR creatinine will be evaluated by the CKD-EPI formula. Moreover, the slope of eGFR (16) will be calculated. Patients, categorized in CKD stages 1 to 3, will be included in the clinical study.

• Proteinuria. Patients will collect 24 hour urine for proteinuria. Values of >0.5 g/ day will be considered abnormal. Proteinuria reduction (geometric mean of 30% within 6 months), time-average proteinuria (TA-P) and slope of proteinuria will be evaluated.

Serum creatinine, proteinuria, age and hypertension have a lower weight when histological lesions are not considered. This finding highlights the importance of the kidney biopsy, not only for diagnosis but for personalized treatment.

• Blood hypertension is defined when values are > 130/80 mmHg or in subjects treated with anti-hypertensive drugs.

• For hyperuricemia allopurinol therapy is recommended.

SAMPLE SIZE CALCULATION.

ACIgAN. Data from the literature show a difference in renal survival between corticosteroids and controls when the researchers assumed a difference of 50% in the primary end point (i.e. in the between-arms difference of delta 24 hour proteinuria from baseline to 6 months) as clinically relevant. We assume that a mean delta proteinuria (±SD) from baseline to 6 months in patients treated with Ramipril alone (control arm) is 0.6±1.0 g/24 hours versus a mean delta proteinuria (±SD) from baseline to 6 months in patients treated with Ramipril and corticosteroids (experimental arm) 1.2±1.0 g/24 hours. Based on these assumptions, we calculated a sample size of 132 patients (66 patients per group including a 10% dropout rate) for a power of 90%, a two-sided significance level of 0.05 and 3 years of recruitment. If the number of the enrolled patients will be insufficient, the recruitment period will be extended for two years. At 4 months, all patients of the control arm who will display a 24 hour proteinuria >0.5g will be switched to the experimental treatment and will receive corticosteroids combined with RASBs for 4 months. They will be followed-up until the study termination.

CHRONIgAN. Data from the literature suggest a difference of renal survival between SGLT2is and controls. Here we assume a difference of 40% in the primary end point (i.e. in the between-arms difference of delta 24 hour proteinuria from baseline to 6 months) as clinically relevant. We assume that a mean delta proteinuria (±SD) from baseline to 6 months in patients with Ramipril alone is 0.6±1.0 g/24 hours versus a mean delta proteinuria (±SD) from baseline to 6 months in patients treated with SGLT-2 inhibitor and Ramipril (1.0±1.0 g/24 hours). Based on these assumptions, we have calculated a sample size of 294 patients (147 patients per group including a 10% dropout rate) for a power of 90%, a two-sided significance level of 0.05 and 3 years of recruitment. If the time-recruitment will be insufficient, the recruitment period will be extended for two years. At 6 months, all patients of the control arm who will display a 24 hour proteinuria >0.5 g will be switched to the experimental treatment (SGLT-2 inhibitor combined with Ramipril). They will be followed-up until the study termination.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 878
• Est. completion date: December 31, 2026
• Est. primary completion date: June 1, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Only adult patients (age 18-70 years) with biopsy-proven idiopathic IgAN.

• IgAN patients with active or chronic or moderate renal lesions

Exclusion Criteria

• Patients with idiopathic IgAN and nephrotic syndrome (minimal change disease at kidney biopsy)

• IgAN patients with hematuria and acute renal failure

• IgAN patients with rapidly progressive glomerulonephritis (extracapillary lesions in more than 50% of glomeruli)

• Patients with secondary IgAN (lupus nephritis, Schoenlein-Henoch purpura, liver cirrhosis)

• Any prior immunosuppressive therapy

• Superimposed IgAN in kidney transplant

• Severe liver diseases

• Infections

• Malignancies

• Pregnancy

• Patients with myocardial infarction or cerebrovascular stroke in the previous 6 months

• Uncontrolled diabetes

• Aseptic necrosis of any bone

• Other conditions that can be exacerbated by corticosteroids

• Previous adverse side effects to RASBs

• Previous adverse side effects to SGLT2is

• Patients with mild renal lesions (M0,E0,S0,T0,C0), minor urinary findings, proteinuria < 0.5 g/day, normal GFR and normal blood pressure

Related Conditions & MeSH terms

• Glomerulonephritis
• Glomerulonephritis, IGA
• Immunoglobulin A Nephropathy
• Kidney Diseases

Intervention

Drug:
• Corticosteroid
To reduce the progression of renal damage in IgAN Patients
• Renin-angiotensin sytem blockers
To reduce the progression of renal damage in IgAN Patients
• Sodium-glucose cotransporter 2 inhibitor
To reduce the progression of renal damage in IgAN Patients

Locations

Country	Name	City	State
Italy	francesco paolo Schena	Bari	BA
Italy	francesco paolo Schena	Bari	BA

Sponsors (2)

Lead Sponsor	Collaborator
Fondazione Schena	University of Bari

Country where clinical trial is conducted

Italy, 

References & Publications (20)

Chapter 10: Immunoglobulin A nephropathy. Kidney Int Suppl (2011). 2012 Jun;2(2):209-217. doi: 10.1038/kisup.2012.23. No abstract available. — View Citation

Heerspink HJL, Stefansson BV, Correa-Rotter R, Chertow GM, Greene T, Hou FF, Mann JFE, McMurray JJV, Lindberg M, Rossing P, Sjostrom CD, Toto RD, Langkilde AM, Wheeler DC; DAPA-CKD Trial Committees and Investigators. Dapagliflozin in Patients with Chronic — View Citation

Kang SH, Choi SR, Park HS, Lee JY, Sun IO, Hwang HS, Chung BH, Park CW, Yang CW, Kim YS, Choi YJ, Choi BS. The Oxford classification as a predictor of prognosis in patients with IgA nephropathy. Nephrol Dial Transplant. 2012 Jan;27(1):252-8. doi: 10.1093/ — View Citation

Koyama A, Igarashi M, Kobayashi M. Natural history and risk factors for immunoglobulin A nephropathy in Japan. Research Group on Progressive Renal Diseases. Am J Kidney Dis. 1997 Apr;29(4):526-32. doi: 10.1016/s0272-6386(97)90333-4. — View Citation

Lea J, Greene T, Hebert L, Lipkowitz M, Massry S, Middleton J, Rostand SG, Miller E, Smith W, Bakris GL. The relationship between magnitude of proteinuria reduction and risk of end-stage renal disease: results of the African American study of kidney disea — View Citation

Levey AS, Eckardt KU, Dorman NM, Christiansen SL, Hoorn EJ, Ingelfinger JR, Inker LA, Levin A, Mehrotra R, Palevsky PM, Perazella MA, Tong A, Allison SJ, Bockenhauer D, Briggs JP, Bromberg JS, Davenport A, Feldman HI, Fouque D, Gansevoort RT, Gill JS, Gre — View Citation

Levin A, Agarwal R, Herrington WG, Heerspink HL, Mann JFE, Shahinfar S, Tuttle KR, Donner JA, Jha V, Nangaku M, de Zeeuw D, Jardine MJ, Mahaffey KW, Thompson AM, Beaucage M, Chong K, Roberts GV, Sunwold D, Vorster H, Warren M, Damster S, Malik C, Perkovic — View Citation

Lv J, Yang Y, Zhang H, Chen W, Pan X, Guo Z, Wang C, Li S, Zhang J, Zhang J, Liu L, Shi S, Wang S, Chen M, Cui Z, Chen N, Yu X, Zhao M, Wang H. Prediction of outcomes in crescentic IgA nephropathy in a multicenter cohort study. J Am Soc Nephrol. 2013 Dec; — View Citation

Lv J, Zhang H, Wong MG, Jardine MJ, Hladunewich M, Jha V, Monaghan H, Zhao M, Barbour S, Reich H, Cattran D, Glassock R, Levin A, Wheeler D, Woodward M, Billot L, Chan TM, Liu ZH, Johnson DW, Cass A, Feehally J, Floege J, Remuzzi G, Wu Y, Agarwal R, Wang — View Citation

Manno C, Strippoli GF, D'Altri C, Torres D, Rossini M, Schena FP. A novel simpler histological classification for renal survival in IgA nephropathy: a retrospective study. Am J Kidney Dis. 2007 Jun;49(6):763-75. doi: 10.1053/j.ajkd.2007.03.013. — View Citation

Orlandi PF, Xie D, Yang W, Cohen JB, Deo R, Ricardo AC, Schrauben S, Wang X, Hamm LL, He J, Sondheimer JH, Kallem K, Townsend R, Raj D, Parsa A, Anderson AH, Feldman HI; CRIC Study Investigators; Chronic Renal Insufficiency Cohort (CRIC) Study Investigato — View Citation

Rauen T, Eitner F, Fitzner C, Sommerer C, Zeier M, Otte B, Panzer U, Peters H, Benck U, Mertens PR, Kuhlmann U, Witzke O, Gross O, Vielhauer V, Mann JF, Hilgers RD, Floege J; STOP-IgAN Investigators. Intensive Supportive Care plus Immunosuppression in IgA — View Citation

Reich HN, Troyanov S, Scholey JW, Cattran DC; Toronto Glomerulonephritis Registry. Remission of proteinuria improves prognosis in IgA nephropathy. J Am Soc Nephrol. 2007 Dec;18(12):3177-83. doi: 10.1681/ASN.2007050526. Epub 2007 Oct 31. — View Citation

Schena FP, Anelli VW, Trotta J, Di Noia T, Manno C, Tripepi G, D'Arrigo G, Chesnaye NC, Russo ML, Stangou M, Papagianni A, Zoccali C, Tesar V, Coppo R; members of the VALIGA study. Development and testing of an artificial intelligence tool for predicting — View Citation

Schena FP, Nistor I. Epidemiology of IgA Nephropathy: A Global Perspective. Semin Nephrol. 2018 Sep;38(5):435-442. doi: 10.1016/j.semnephrol.2018.05.013. — View Citation

Shen XH, Liang SS, Chen HM, Le WB, Jiang S, Zeng CH, Zhou ML, Zhang HT, Liu ZH. Reversal of active glomerular lesions after immunosuppressive therapy in patients with IgA nephropathy: a repeat-biopsy based observation. J Nephrol. 2015 Aug;28(4):441-9. doi — View Citation

Shi SF, Wang SX, Jiang L, Lv JC, Liu LJ, Chen YQ, Zhu SN, Liu G, Zou WZ, Zhang H, Wang HY. Pathologic predictors of renal outcome and therapeutic efficacy in IgA nephropathy: validation of the oxford classification. Clin J Am Soc Nephrol. 2011 Sep;6(9):21 — View Citation

Trimarchi H, Barratt J, Cattran DC, Cook HT, Coppo R, Haas M, Liu ZH, Roberts IS, Yuzawa Y, Zhang H, Feehally J; IgAN Classification Working Group of the International IgA Nephropathy Network and the Renal Pathology Society; Conference Participants. Oxfor — View Citation

Working Group of the International IgA Nephropathy Network and the Renal Pathology Society; Cattran DC, Coppo R, Cook HT, Feehally J, Roberts IS, Troyanov S, Alpers CE, Amore A, Barratt J, Berthoux F, Bonsib S, Bruijn JA, D'Agati V, D'Amico G, Emancipator — View Citation

Working Group of the International IgA Nephropathy Network and the Renal Pathology Society; Roberts IS, Cook HT, Troyanov S, Alpers CE, Amore A, Barratt J, Berthoux F, Bonsib S, Bruijn JA, Cattran DC, Coppo R, D'Agati V, D'Amico G, Emancipator S, Emma F, — View Citation

* Note: There are 20 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	-Proteinuria reduction within 6 months in IgAN patients with active renal lesions	Reduction of proteinuria will be calculated as difference betweeen arms within 6 months	6th month
Primary	Proteinuria reduction within 6 months in IgAN patients with active renal lesions	Reduction of proteinuria will be calculated as difference betweeen arms within every 6 months	12th month
Primary	Proteinuria reduction within 6 months in IgAN patients with active renal lesions	Reduction of proteinuria will be calculated as difference betweeen arms within every 6 months	18th month
Primary	Proteinuria reduction within 6 months in IgAN patients with active renal lesions	Reduction of proteinuria will be calculated as difference betweeen arms within every 6 months	24th month
Primary	Proteinuria reduction within 6 months in IgAN patients with active renal lesions	Reduction of proteinuria will be calculated as difference betweeen arms within every 6 months	30th month
Primary	Proteinuria reduction within 6 months in IgAN patients with active renal lesions	Reduction of proteinuria will be calculated as difference betweeen arms within every 6 months	36th month
Primary	Proteinuria reduction within 6 months in IgAN patients with chronic renal lesions	Reduction of proteinuria will be calculated as difference betweeen arms within every 6 months	6th month
Primary	Proteinuria reduction within 6 months in IgAN patients with chronic renal lesions	Reduction of proteinuria will be calculated as difference betweeen arms within every 6 months	12th month
Primary	Proteinuria reduction within 6 months in IgAN with chronic renal lesions	Reduction of proteinuria will be calculated as difference betweeen arms within every 6 months	18th month
Primary	Proteinuria reduction within 6 months in IgAN patients with chronic renal lesions	Reduction of proteinuria will be calculated as difference betweeen arms within every 6 months	24th month
Primary	Proteinuria reduction within 6 months in IgAN with chronic renal lesions	Reduction of proteinuria will be calculated as difference betweeen arms within every 6 months	30th month
Primary	Proteinuria reduction within 6 months in IgAN with chronic renal lesions	Reduction of proteinuria will be calculated as difference betweeen arms within every 6 months	36th month
Secondary	eGFR slope change in IgAN patients with active renal lesions	eGFR slope change calculated as the mean of the individual slopes obtained from individual linear regression of eGFR over time;	6th month
Secondary	eGFR slope change in IgAN patients with active renal lesions	eGFR slope change calculated as the mean of the individual slopes obtained from individual linear regression of eGFR over time;	12th month
Secondary	eGFR slope change in IgAN patients with active renal lesions	eGFR slope change calculated as the mean of the individual slopes obtained from individual linear regression of eGFR over time;	18th month
Secondary	eGFR slope change in IgAN patients with active renal lesions	eGFR slope change calculated as the mean of the individual slopes obtained from individual linear regression of eGFR over time;	24th month
Secondary	eGFR slope change in IgAN patients with active renal lesions	eGFR slope change calculated as the mean of the individual slopes obtained from individual linear regression of eGFR over time;	30th month
Secondary	eGFR slope change in IgAN patients with active renal lesions	eGFR slope change calculated as the mean of the individual slopes obtained from individual linear regression of eGFR over time;	36th month
Secondary	eGFR slope change in IgAN patients with chronic renal lesions	eGFR slope change calculated as the mean of the individual slopes obtained from individual linear regression of eGFR over time;	6th month
Secondary	eGFR slope change in IgAN patients with chronic renal lesions	eGFR slope change calculated as the mean of the individual slopes obtained from individual linear regression of eGFR over time;	12th month
Secondary	eGFR slope change in IgAN patients with chronic renal lesions	eGFR slope change calculated as the mean of the individual slopes obtained from individual linear regression of eGFR over time;	18th month
Secondary	eGFR slope change in IgAN patients with chronic renal lesions	eGFR slope change calculated as the mean of the individual slopes obtained from individual linear regression of eGFR over time;	24th month
Secondary	eGFR slope change in IgAN patients with chronic renal lesions	eGFR slope change calculated as the mean of the individual slopes obtained from individual linear regression of eGFR over time;	30th month
Secondary	eGFR slope change in IgAN patients with chronic renal lesions	eGFR slope change calculated as the mean of the individual slopes obtained from individual linear regression of eGFR over time;	36th month
Secondary	eGFR decline >40% in IgAN patients with active renal lesions	eGFR decline >40% in IgAN patients with active renal lesions	6th month
Secondary	eGFR decline >40% in IgAN patients with active renal lesions	eGFR decline >40% in IgAN patients with active renal lesions	12th month
Secondary	eGFR decline >40% in IgAN patients with active renal lesions	eGFR decline >40% in IgAN patients with active renal lesions	18th month
Secondary	eGFR decline >40% in IgAN patients with active renal lesions	eGFR decline >40% in IgAN patients with active renal lesions	24th month
Secondary	eGFR decline >40% in IgAN patients with active renal lesions	eGFR decline >40% in IgAN patients with active renal lesions	30th month
Secondary	eGFR decline >40% in IgAN patients with active renal lesions	eGFR decline >40% in IgAN patients with active renal lesions	36th month
Secondary	eGFR decline >40% in IgAN patients with chronic renal lesions	eGFR decline >40% in IgAN patients with chronic renal lesions	6th month
Secondary	eGFR decline >40% in IgAN patients with chronic renal lesions	eGFR decline >40% in IgAN patients with chronic renal lesions	12th month
Secondary	eGFR decline >40% in IgAN patients with chronic renal lesions	eGFR decline >40% in IgAN patients with chronic renal lesions	18th month
Secondary	eGFR decline >40% in IgAN patients with chronic renal lesions	eGFR decline >40% in IgAN patients with chronic renal lesions	24th month
Secondary	eGFR decline >40% in IgAN patients with chronic renal lesions	eGFR decline >40% in IgAN patients with chronic renal lesions	30th month
Secondary	eGFR decline >40% in IgAN patients with chronic renal lesions	eGFR decline >40% in IgAN patients with chronic renal lesions	36th month
Secondary	composite endpoint: eGFR decline > 40%, ESKD (defined as long-term eGFR < 15 ml/min/1.73m2 for more than 3 months or need of maintenance dialysis or kidney transplantation) and death due to kidney disease in IgAN patients with active renal lesions	composite endpoint: eGFR decline > 40%, ESKD (defined as long-term eGFR < 15 ml/min/1.73m2 for more than 3 months or need of maintenance dialysis or kidney transplantation) and death due to kidney disease in IgAN patients with active renal lesions	6th month
Secondary	composite endpoint: eGFR decline > 40%, ESKD (defined as long-term eGFR < 15 ml/min/1.73m2 for more than 3 months or need of maintenance dialysis or kidney transplantation) and death due to kidney disease in IgAN patients with active renal lesions	composite endpoint: eGFR decline > 40%, ESKD (defined as long-term eGFR < 15 ml/min/1.73m2 for more than 3 months or need of maintenance dialysis or kidney transplantation) and death due to kidney disease in IgAN patients with active renal lesions	12th month
Secondary	composite endpoint: eGFR decline > 40%, ESKD (defined as long-term eGFR < 15 ml/min/1.73m2 for more than 3 months or need of maintenance dialysis or kidney transplantation) and death due to kidney disease in IgAN patients with active renal lesions	composite endpoint: eGFR decline > 40%, ESKD (defined as long-term eGFR < 15 ml/min/1.73m2 for more than 3 months or need of maintenance dialysis or kidney transplantation) and death due to kidney disease in IgAN patients with active renal lesions	18th month
Secondary	composite endpoint: eGFR decline > 40%, ESKD and death due to kidney disease in IgAN patients with active renal lesions	composite endpoint: eGFR decline > 40%, ESKD (defined as long-term eGFR < 15 ml/min/1.73m2 for more than 3 months or need of maintenance dialysis or kidney transplantation) and death due to kidney disease in IgAN patients with active renal lesions	24th month
Secondary	composite endpoint: eGFR decline > 40%, ESKD and death due to kidney disease in IgAN patients with active renal lesions	composite endpoint: eGFR decline > 40%, ESKD (defined as long-term eGFR < 15 ml/min/1.73m2 for more than 3 months or need of maintenance dialysis or kidney transplantation) and death due to kidney disease in IgAN patients with active renal lesions	30th month
Secondary	composite endpoint: eGFR decline > 40%, ESKD and death due to kidney disease in IgAN patients with active renal lesions	composite endpoint: eGFR decline > 40%, ESKD (defined as long-term eGFR < 15 ml/min/1.73m2 for more than 3 months or need of maintenance dialysis or kidney transplantation) and death due to kidney disease in IgAN patients with active renal lesions	36th month
Secondary	composite endpoint: eGFR decline > 40%, ESKD and death due to kidney disease in IgAN patients with chronic renal lesions	composite endpoint: eGFR decline > 40%, ESKD (defined as long-term eGFR < 15 ml/min/1.73m2 for more than 3 months or need of maintenance dialysis or kidney transplantation) and death due to kidney disease in IgAN patients with chronic rena lesions	6th month
Secondary	composite endpoint: eGFR decline > 40%, ESKD and death due to kidney disease in IgAN patients with chronic renal lesions	composite endpoint: eGFR decline > 40%, ESKD (defined as long-term eGFR < 15 ml/min/1.73m2 for more than 3 months or need of maintenance dialysis or kidney transplantation) and death due to kidney disease in IgAN patients with chronic rena lesions	12th month
Secondary	composite endpoint: eGFR decline > 40%, ESKD and death due to kidney disease. in IgAN patients with chronic renal lesions	composite endpoint: eGFR decline > 40%, ESKD (defined as long-term eGFR < 15 ml/min/1.73m2 for more than 3 months or need of maintenance dialysis or kidney transplantation) and death due to kidney disease in IgAN patients with chronic renal lesions	18th month
Secondary	composite endpoint: eGFR decline > 40%, ESKD and death due to kidney disease. in IgAN patients with chronic renal lesions	composite endpoint: eGFR decline > 40%, ESKD (defined as long-term eGFR < 15 ml/min/1.73m2 for more than 3 months or need of maintenance dialysis or kidney transplantation) and death due to kidney disease in IgAN patients with chronic renal lesions	24th month
Secondary	composite endpoint: eGFR decline > 40%, ESKD and death due to kidney disease. in IgAN patients with chronic renal lesions	composite endpoint: eGFR decline > 40%, ESKD (defined as long-term eGFR < 15 ml/min/1.73m2 for more than 3 months or need of maintenance dialysis or kidney transplantation) and death due to kidney disease in IgAN patients with chronic renal lesions	30th month
Secondary	composite endpoint: eGFR decline > 40%, ESKD and death due to kidney disease. in IgAN patients with chronic renal lesions	composite endpoint: eGFR decline > 40%, ESKD (defined as long-term eGFR < 15 ml/min/1.73m2 for more than 3 months or need of maintenance dialysis or kidney transplantation) and death due to kidney disease in IgAN patients with chronic renal lesions	36th month
Secondary	proteinuria reduction (geometric mean of 30% within 6 months)	proteinuria reduction in IgAN patients with chronic renal lesions	6th month
Secondary	proteinuria reduction (geometric mean of 30% within 6 months)	proteinuria reduction in IgAN patients with chronic renal lesions	12th month
Secondary	proteinuria reduction (geometric mean of 30% within 6 months)	proteinuria reduction in IgAN patients with chronic renal lesions	18th month
Secondary	proteinuria reduction (geometric mean of 30% within 6 months)	proteinuria reduction in IgAN patients with chronic renal lesions	24th month
Secondary	proteinuria reduction (geometric mean of 30% within 6 months)	proteinuria reduction in IgAN patients with chronic renal lesions	30th month
Secondary	proteinuria reduction (geometric mean of 30% within 6 months)	proteinuria reduction in IgAN patients with chronic renal lesions	36th month
Secondary	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement in IgAN patients with active renal lesions	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement	3rd month
Secondary	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement in IgAN patients with active renal lesions	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement	6th month
Secondary	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement in IgAN patients with active renal lesions	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement	9th month
Secondary	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement in IgAN patients with active renal lesions	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement	12th month
Secondary	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement in IgAN patients with active renal lesions	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement	18th month
Secondary	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement in IgAN patients with active renal lesions	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement	24th month
Secondary	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement in IgAN patients with active renal lesions	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement	30th month
Secondary	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement in IgAN patients with active renal lesions	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement	36th month
Secondary	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement in IgAN patients with chronic renal lesions	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement	6th month
Secondary	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement in IgAN patients with chronic renal lesions	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement	12th month
Secondary	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement in IgAN patients with chronic renal lesions	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement	18th month
Secondary	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement in IgAN patients with chronic renal lesions	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement	24th month
Secondary	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement in IgAN patients with chronic renal lesions	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement	30th month
Secondary	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement in IgAN patients with chronic renal lesions	time-averaged proteinuria (TA-P) calculated as the weighted mean of all post-randomization measurement, with weights representing the time elapsed since the previous measurement	36 th month