Glomerulonephritis Clinical Trial
Official title:
Phase 1 Study of Systemic Effects of Ng-Monomethyl-L-Arginine on Renal Hemodynamics in Patients With Polycystic Kidney Disease and Chronic Glomerulonephritis
The study tests the hypothesis that systemic and renal nitric oxide availability is changed in polycystic kidney disease and chronic glomerulonephritis.
In a randomized, placebo controlled design, the effects of systemic treatment with
monomethyl-L-arginine are studied on:
1. renal hemodynamics
2. renal sodium excretion and lithium clearance
3. blood pressure and heart rate
4. plasma levels of vasoactive hormones
in patients with adult polycystic kidney disease and chronic glomerulonephrits. The results
are compared with a group of healthy control subjects
;
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind
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