Glomerular Filtration Rate Clinical Trial
Official title:
Effect of Elevated Plasma-Free-Fatty-Acids on Renal Hemodynamic Parameters
Type 2 diabetes is frequently associated with elevation of plasma-free fatty acids (FFA).
Studies indicate that elevation of plasma-FFA induces insulin resistance and also causes
endothelial dysfunction as well as hemodynamic changes which are supposed to be involved in
the pathogenesis of diabetic vascular disorders.
Glomerular hyperfiltration, which is associated with glomerular hypertension and
hypertrophy, a common finding in the early course of type 1 diabetes as well as type 2
diabetes, plays an important role in the development and progression of diabetic
nephropathy. These hemodynamic changes are not well understood, but are most likely induced
by dilatation of the (precapillary) glomerular arteriole.
In humans the hemodynamic effect of FFAs has so far been investigated locally in brachial
and femoral arteries and recently in the eye and skin, where FFAs induced a pronounced
increase in blood flow probably due to a local decrease in vascular resistance.
The aim of the present study is to characterise the hemodynamic effects of FFAs in the
kidney. In addition we want to test the hypothesis that FFA-induced changes are mediated via
endothelial derived nitric oxide (NO). The results of this study could provide information
to what extent elevated FFA-plasma levels contribute to hyperfiltration in the early course
of diabetes mellitus. The measurements will be done at baseline and during 4 hour infusion
of a triglyceride or placebo infusion, combined with heparin.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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