Clinical Trials Logo

Clinical Trial Summary

The key molecular changes in the progression of glioma are closely related to tumor heterogeneity, pathological grade, precision treatment and prognosis of glioma. At present, a visually quantitative assessment criteria about the key molecular typing of glioma is still absent. Based on the previous research, this project intends to establish a multi-dimensional database of glioma from clinical, radiomics and microomics levels. The investigators aim to filter out the specific molecular markers in the progression of glioma and explore the intrinsic connection of radiomics features and microomics molecular markers by using bioinformatics integration analysis and artificial intelligence multiple kernel learning. Thus, the investigators could determine the specific molecular mechanism in the progression of glioma, and establish a visually quantitative assessment system of pre-operative precisive grading, molecular typing discrimination and prognosis prediction. The completion of this project is of great significance for improving molecular diagnostic level of glioma, guiding individualized diagnosis and treatment decisions, and improving the survival rate of patients.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03750890
Study type Observational [Patient Registry]
Source Tongji Hospital
Contact Wenzhen Zhu, doctor
Phone 8613886018612
Email zhuwenzhen8612@163.com
Status Recruiting
Phase
Start date January 1, 2019
Completion date December 31, 2022

See also
  Status Clinical Trial Phase
Withdrawn NCT03796507 - Early Temozolomide in Patients With High-Grade Gliomas in Rehabilitation Early Phase 1
Withdrawn NCT04406610 - CAR-T Cell Immunotherapy for GD2 Positive Glioma Patients Phase 1/Phase 2
Active, not recruiting NCT03665545 - Pembrolizumab in Association With the IMA950/Poly-ICLC for Relapsing Glioblastoma Phase 1/Phase 2
Active, not recruiting NCT03189420 - Glioma Microenvironment an Exploratory Study
Completed NCT03194906 - Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors Phase 2
Active, not recruiting NCT03739372 - Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma N/A
Completed NCT03779230 - Safety and Efficacy of L19TNF in Patients With Isocitrate Dehydrogenase (IDH) Wildtype WHO Grade III / IV Glioma at First Relapse Phase 1/Phase 2
Recruiting NCT03728673 - A Study Utilizing Escitalopram in Glioma Patients Phase 2
Active, not recruiting NCT03496181 - Evaluation of Functional Magnetic Resonance Imaging (fMRI) in Patients Who Speak Two Languages Fluently
Recruiting NCT03180697 - The Efficacy of APT Magnetic Resonance Imaging in Predicting the Efficacy of Bevacizumab in Recurrent Malignant Gliomas N/A
Recruiting NCT03949192 - Efficacy of Kangliuwan for Recurrent Grade IV Glioma
Terminated NCT03927274 - Intratumorally-Administered Topotecan Using Convection-Enhanced Delivery in Patients With Grade III/ IV Glioma Early Phase 1
Recruiting NCT03213002 - Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM Phase 1/Phase 2
Not yet recruiting NCT03763396 - Azoles Targeting Recurrent High Grade Gliomas Early Phase 1
Terminated NCT03698201 - Blood Biomarker Signature in Glioma
Terminated NCT03436433 - Seizure Prophylaxis in Patients With Glioma or Brain Metastasis Phase 2
Enrolling by invitation NCT03102112 - Noninvasively Predicting Gene Status of Glioma N/A
Active, not recruiting NCT03935685 - Pilot Study of Mirtazapine for the Dual Tx of Depression and CINV in High-Grade Glioma Pts on TMZ Phase 2
Completed NCT03834740 - A Phase 0 /II Study of Ribociclib (LEE011) in Combination With Everolimus in Preoperative Recurrent High-Grade Glioma Patients Scheduled for Resection Early Phase 1
Recruiting NCT03849430 - Longitudinal Analysis of the Health-related Quality of Life in Glioma Patients