Glioma of Brain Clinical Trial
Official title:
A Large-scale Research for Immunotherapy of Glioblastoma With Autologous Heat Shock Protein gp96
This trial is to further study the safety and effectiveness of autologous gp96 treatment of glioblastoma on the basis of preliminary work.
RATIONALE: heat shock protein gp96-peptide complex made from a person's tumor cells may help
the body build an effective immune response to kill tumor cells.
Overall Goals:
- to evaluate the safety and induction of anti-tumor immunity by administration of an
immunogenic human tumor cell vaccine, and assess immune response in relation to clinical
outcome.
Primary Aim:
- to further evaluate effectiveness of autologous gp96 treatment of glioblastoma on the basis
of preliminary work.
Secondary Aims:
to study the immune response to vaccination, to monitor clinical responses , to further the
safety of vaccine.
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