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NCT05793021 Clinical Trial

FKBP51s: a New Molecular Biomarker for Glioblastoma? Pre- and Post-operative Blood Levels Evaluation of FKBP51s Protein and Correlation With MRI Phenotype

Glioblastoma Clinical Trial

Official title:
FKBP51s: a New Molecular Biomarker for Glioblastoma? Pre- and Post-operative Blood Levels Evaluation of FKBP51s Protein and Correlation With MRI Phenotype

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05793021
Other study ID # 3751
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date July 8, 2021
Est. completion date December 31, 2025

Study information
Verified date February 2023
Source Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Contact Simona Gaudino, MD
Phone 0630155464
Email simona.gaudino@policlinicogemelli.it
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The aim of this interventional study is to investigate the correlation between Magnetic Resonance Phenotype and levels of FKBP51s protein pre and post surgery in adult patients affected by Glioblastoma

Recruitment information / eligibility
Status Recruiting
Enrollment 70
Est. completion date December 31, 2025
Est. primary completion date December 31, 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Age >= 18 years - Diagnosis of Glioblastoma with surgery criteria - Brain MRI with contrast both pre and post surgery Exclusion Criteria: - No availability of radiological documentation - Glioblastoma diagnosis not confirmed by Histological examination - Withdrawal of ICF

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Blood sample
Blood sample pre and post surgery to determine the level of FKBP51s protein

Locations
Country Name City State
Italy Fondazione Policlinico Universitaro "A. Gemelli" IRCCS Roma

Sponsors (1)
Lead Sponsor Collaborator
Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Country where clinical trial is conducted

Italy, 

Outcome
Type Measure Description Time frame Safety issue
Primary Correlation between FKBP51s protein concentration in Blood Cells and Disease flow 1 week
Primary Correlation between FKBP51s protein concentration in Blood Cells and Disease flow 3 months
Secondary Correlation between FKBP51s protein concentration in Blood Cells and PDL1 expression, Brain MRI phenotype and survival 1 year
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