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Biopsy Versus Resection in Elderly Glioblastoma Patients. A Prospective Cohort Study. — BIOPSY  

Glioblastoma Clinical Trial

Official title:
Biopsy Versus Resection in Elderly Glioblastoma Patients. A Prospective Cohort Study.

Clinical Trial Summary

This trial is set up as a prospective observational cohort study to identify if either biopsy or resection should be the surgical modality of choice in elderly glioblastoma patients with a newly diagnosed tumor. Patients who are considered eligible for GBM resection or biopsy will be included. Through shared-decision making patients and their treating physicians will decide upon resection or biopsy. Written informed consent will be obtained. Participants will be followed for 1 year postoperative to assess potential differences in health-related quality of life and overall survival. Follow-up will consist of health-related quality of life questionaires and neurological assessment at 6 weeks, 3 months, 6 months and 12 months postoperative. Additionally Cognitive and neuro-linguistic tests will be done at 3 months postoperative. These will be compared to results pre-operative. After surgery, patients will receive standard adjuvant treatment with concomitant Temozolomide and radiation therapy, and standard follow-up. Patients in whom the diagnosis GBM is not confirmed in histological analyses will be excluded from the study. Total study duration will be 4 years, of which 3 years will comprise patient inclusion, with a follow-up duration of 1 year.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05641220
Study type Observational
Source Erasmus Medical Center
Contact Yvette de Haan, drs
Phone +31612594000
Email y.dehaan@erasmusmc.nl
Status Not yet recruiting
Phase
Start date January 1, 2023
Completion date January 1, 2027
View Details
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