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Glioblastoma Radiotherapy Using IMRT or Proton Beams — GRIPS  

Glioblastoma Clinical Trial

Official title:
Glioblastoma Radiotherapy Using IMRT or Proton Beams

Clinical Trial Summary

Radiation therapy is an integral part of the multimodal primary therapy of glioblastomas. As the overall prognosis in this tumor entity remains unfavorable, current research is focused on additional drug therapies, which are often accompanied by increases in toxicity. By using proton beams instead of photon beams, it is possible to protect large parts of the brain which are not affected by the tumor more effectively. An initial retrospective matched-pair analysis showed that this theoretical physical benefit is also clinically associated with a reduction in toxicity during therapy and in the first few months thereafter. The aim of the GRIPS study is to prospectively test this clinical benefit in a randomized, open-label Phase III study. Patients are treated in the study using either modern photon radiation techniques (standard arm) or proton beams (experimental arm). The primary endpoint is the cumulative toxicity CTC grade 2 and higher in the first 4 months. Secondary endpoints include overall survival, progression-free survival, quality of life, and neurocognition.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04752280
Study type Interventional
Source University Hospital Heidelberg
Contact Klaus Herfarth, Prof. Dr.
Phone +49 6221 56 34093
Email studienkoordination.RAD@med.uni-heidelberg.de
Status Recruiting
Phase N/A
Start date April 19, 2021
Completion date October 19, 2027
View Details
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