Glioblastoma Clinical Trial
Official title:
Early Diagnosis of Pseudoprogression Using 11C-Methionine PET-MRI After Concomitant Radiochemotherapy Treatment for Glioblastoma.
Pseudoprogression is a phenomenon related to post-treatment rearrangements (including
radiation necrosis). It appears early in the first year after treatment and accounts for 30
to 50% of patients followed with glioblastoma. On MRI (current gold standard with
international therapeutic response evaluation criteria RANO 2010), pseudoprogression is
manifested by a progression of morphological abnormalities (contrast enhancement, FLAIR
hypersignal) and can simulate tumor recurrence, even though the corticosteroid improved or
kept clinical symptoms stabilized. In view of prognosis, the current diagnostic tools have
not enough diagnosis accuracy for differentiation between pseudo-progression and early tumor
recurrence, and are based on MRI retrospective analysis (2-3 months after). Recurrence of
glioblastoma, is characterized by a higher amino acid metabolism than pseudoprogression, also
11C-Methionine (11C-MET), positron emitting radiotracer, showed promising results to
differentiate these two entities. To date, hybrid 11C-MET PET-MRI studies remains limited to
small sample size (a few dozen patients), and none focuses exclusively on glioblastoma.
Hypothesis of our study is that 11C-MET PET-MRI may be performed as a first-line MRI for
suspected pseudoprogression and may changes therapeutic decision making and also patient
prognosis.
The main objective is to evaluate the performance of hybrid PET-MRI imaging with 11C-MET to
differentiate pseudoprogression from glioblastoma recurrence in patients treated with surgery
and radiochemotherapy, compared to multimodality MRI).
n/a
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