DNX-2440 Oncolytic Adenovirus for Recurrent Glioblastoma

Status Terminated

Clinical Trial Summary

Patients with first or second recurrence of GBM will be treated with stereotactic injection of the oncolytic virus DNX-2440.

Clinical Trial Description

After inclusion in the trial, stereotactic biopsy will be performed. In the same surgery, the experimental agent will be injected also by stereotactic system, in a different part of the lesion, in a region considered viable tumor, using a cannula especially designed for virus injection. Follow-up will include clinical visits and MRI No other treatment for the tumor will be used until progression is documented. iRANO criteria and volumetric measurement of the tumor will be used. Any further treatment after progression will be at the criteria of the treating physician ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03714334
Study type	Interventional
Source	Clinica Universidad de Navarra, Universidad de Navarra
Contact
Status	Terminated
Phase	Phase 1
Start date	October 16, 2018
Completion date	April 5, 2023

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