Testing Ramipril to Prevent Memory Loss in People With Glioblastoma

Status Active, not recruiting

Clinical Trial Summary

This study is to determine if an oral drug called Ramipril can lower the chance of memory loss in patients with glioblastoma getting chemoradiation. Patients will take Ramipril during chemoradiation and continue until 4 months post-treatment. Memory loss will be assessed using several neurocognitive tests throughout the duration of the study.

Clinical Trial Description

This is a pilot study of an oral drug Ramipril to prevent cognitive decline in glioblastoma patients receiving partial brain radiation and concurrent and adjuvant temozolomide . Ramipril will be titrated to the highest tolerable dose during chemoradiation (2.5-5 mg). Once this dose is determined, the patient will continue at this dose for 4 months after the completion of chemoradiation. Patients will be followed until 5 months post chemoradiation for compliance, toxicity, cognitive decline and participant reported outcomes (PRO). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03475186
Study type	Interventional
Source	Wake Forest University Health Sciences
Contact
Status	Active, not recruiting
Phase	Phase 2
Start date	March 25, 2019
Completion date	July 31, 2024

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