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Bevacizumab and Nimustine in Patients With Recurrent High Grade Glioma

Glioblastoma Clinical Trial

Official title:
Phase II Study of Bevacizumab and Nimustine in Patients With Recurrent High Grade Glioma

Clinical Trial Summary

The purpose of this study is to determine whether bevacizumab and nimustine are effective in the treatment of recurrent high grade glioma and to explore whether there is any subgroup being sensitive to this therapeutic protocol.

Clinical Trial Description

Although anti-angiogenesis therapy for glioblastoma(GBM) are showing promise, GBMs often develop resistance to treatment within months or weeks after salvage therapy. There are still no effective markers to predict the response rate to bevacizumab.

So the investigators initiate a single-arm Phase II study to evaluate the efficacy and tolerability of bevacizumab and nimustine regimen and to explore the predictive markers in patients with recurrent high-grade glioma. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02698280
Study type Interventional
Source Huashan Hospital
Contact
Status Completed
Phase Phase 2
Start date July 2015
Completion date May 2018
View Details
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