Glioblastoma Clinical Trial
Official title:
Spatial Analysis and Validation of Glioblastoma on 7 T MRI
Currently, patients with a glioblastoma multiforme (GBM) are treated with a combination of
different therapeutic modalities including resection, concurrent chemo- and radiotherapy and
adjuvant temozolomide. However, survival is still poor and most of these tumours recur within
one to two years within the previously irradiated target volume.
The radiation target volume encompasses both the contrast-enhanced lesion on T1-weighted
magnetic resonance imaging (MRI), plus a 1.5 - 2 cm isotropic margin in order to include
microscopic speculated growth. These margins result in a high dose to surrounding healthy
appearing brain tissue. Moreover, the short progression-free survival indicates a possible
geographical miss. There is a clear need for novel imaging techniques in order to better
determine the degree of tumour extent at the time of treatment and to minimize the dose to
healthy brain tissue.
The development of Ultra-High Field (UHF) MRI at a magnetic field strength of 7 Tesla (T)
provides an increased ability to detect, quantify and monitor tumour activity and determine
post-treatment effects on the normal brain tissue as a result of a higher resolution, greater
coverage and shorter scan times compared to 1.5 T and 3 T images. Up to now, only few
investigators have examined the use of UHF MRI in patients with malignant brain tumours.
These studies show its potential to assess tumour microvasculature and post-radiation effects
such as microhaemorrhages.
This study analyzes the accuracy of the 7T MRI in identifying the gross tumour volume (GTV)
in patients with an untreated GBM by comparing biopsy results to 7T images. These biopsies
will be taken from suspected regions of GBM based on 7T MRI that do not appear as such on 3T
MRI. We hypothesize that with the 7T MRI the GTV can be more accurately and extensively
identified when compared to the 3T MRI.
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